Publications by authors named "Aleksandra Grzywacz"
Article Synopsis
- Breast conserving treatment usually includes surgery to remove tumors followed by radiotherapy, but accurately identifying the tumor bed can result in unnecessary radiation to healthy tissue. Preoperative stereotactic body radiotherapy (SBRT) aims to target the tumor more precisely.
- A systematic review was conducted analyzing ten clinical trials involving 188 patients, focusing on early toxicity and cosmetic results of SBRT, with median follow-up of 15 months. Treatments varied in radiation doses and fractionation methods.
- Findings showed low rates of acute and late toxicity and excellent cosmetic outcomes for most patients. Pathological complete response rates improved with longer intervals between SBRT and surgery and when combined with other therapies, suggesting SBRT’s potential to
Therapeutic application of bacterial viruses (phage therapy) has in recent years been rediscovered by many scientists, as a method which may potentially replace conventional antibacterial strategies. However, one of the main problems related to phage application is the stability of bacterial viruses. Though many techniques have been used to sustain phage activity, novel tools are needed to allow long-term phage storage and application in versatile forms.
View Article and Find Full Text PDFEvaluation of the Antitumor Activity of Quaternary Ammonium Surfactants.
Int J Mol Sci
December 2023
Quaternary ammonium surfactants, due to their diverse chemical structure and their biological properties, can be used in medicine as DNA carriers, disinfectants, and antimicrobial and antitumor agents. In this study, using melanoma A375, colon adenocarcinoma HT-29 and normal human dermal fibroblast (NHDF) cells, we tested the hypothesis that the quaternary ammonium surfactants 2-dodecanoyloxyethyl)trimethylammonium bromide (DMM-11), 2-dodecanoyloxypropyl)trimethylammonium bromide (DMPM-11) and 2-pentadecanoyloxymethyl)trimethylammonium bromide (DMGM-14) act selectively against cancer cells. The results showed that these compounds led to the initiation of the apoptotic process of programmed cell death, as evidenced by the ratio of the relative expression of Bax protein to Bcl-2.
View Article and Find Full Text PDFChallenges in the Medical and Psychosocial Care of the Paediatric Refugee-A Systematic Review.
Int J Environ Res Public Health
August 2022
Background: After the invasion of Ukraine, neighbouring countries were forced to find systemic solutions to provide medical care to those fleeing the war, including children, as soon as possible. In order to do this, it is necessary to know the communication problems with refugee minors and find proposals for their solutions.
Methods: A systematic review of the literature from 2016 to 2022 was conducted according to PRISMA criteria.