Can Radiotherapy Quality Assurance (RT QA) improve nasopharyngeal cancer outcomes in low- and middle-income countries (LMICs) - Reporting the technical component of the second phase of a prospective International Atomic Energy Agency (IAEA) study (E33039).

Title: Can Radiotherapy Quality Assurance (RT QA) improve nasopharyngeal cancer (NPC) outcomes in low- and middle-income countries (LMICs) -Reporting phase 2 of a prospective International Atomic Energy Agency (IAEA) study (E33039).

Background: Most of new NPC cases occur in LMICs, but these patients experience poorer survival than new NPC cases in high income countries. This study seeks to determine whether a radiotherapy quality assurance (RT QA) programme can improve NPC patient outcomes in LMICs.

Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.

Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.

Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity.

Caffeine is the most widely consumed psychoactive substance globally, yet its peripheral physiological effects remain incompletely understood. Leveraging comprehensive data from 13,091 blood donors in the REDS RBC-Omics study, we identify caffeine as a significant modulator of red blood cell (RBC) storage quality and transfusion outcomes. Elevated caffeine levels were reproducible across multiple donations from 643 recalled donors, selected based on their extremes in hemolytic propensity.

A Practical Approach to the Diagnosis and Management of Hepatic Encephalopathy.

A Practical Approach to the Diagnosis and Management of Hepatic Encephalopathy] Hepatic encephalopathy (HE) is a common complication of decompensated cirrhosis that can be reversed with treatment. Frequent episodes of recurrence are common, impacting patients, caregivers and healthcare systems, increasing morbidity and mortality statistics and resulting in grave financial consequences. Uptake and adherence to formal recommendations for HE diagnosis and management are low.