Plasma cfDNA analysis of alectinib resistance-related gene alterations in the J-ALEX study.

Background: Resistance to alectinib, the standard first-line therapy for anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC), remains a major clinical challenge. This study aimed to investigate resistance mechanisms using next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA).

Materials And Methods: Plasma samples from 67 patients in the alectinib group of the J-ALEX study were collected at baseline, on day 57, and at treatment discontinuation.

Crystallization of Biobased Long-Chain Aliphatic Polyesters as Sustainable Polymers: Effects of the Diol Structure in the Monomer Unit.

Biobased polyesters, recyclable sustainable polymers derived from renewable feedstock, are promising alternatives to petroleum-based polymers. The crystallization behavior, crystal structure, and supramolecular structures of a series of biobased long-chain aliphatic polyesters, consisting of a diester of 10-undecenoic acid with isosorbide (IS), isomannide (IM), and butanediol (BD) as the midsegments, were studied by various scattering methods and Raman spectroscopy. Polyesters containing butanediol-type midsegments (CBD) participated in the crystallization by being incorporated into the orthorhombic polyethylene crystal lamellae.

The JSH Morning Hypertension Eradication Program Project.

Hypertension is the greatest risk factor for cardiovascular diseases and significantly contributes to cardiovascular mortality. In Japan, the hypertensive population is estimated at 43 million, with only 27% achieving well-controlled blood pressure (BP). The onset of major cardiovascular events, including stroke, myocardial infarction, heart failure, and aortic dissection, frequently occurs during the early morning hours.

Kiosk blood pressure measurement in Japan: clinical and population application.

Kiosk blood pressure measurement refers to the self-measurement of blood pressure unattended by medical staff using an automated device in workplaces or public spaces, e.g., gymnasiums, shopping malls, or governmental facilities.