[Pathomorphological characteristics of inflammatory and hereditary myopathies].

Objective: To characterize the immunophenotypic features of the inflammatory infiltrate cell composition and the morphometric features of muscle fibers in skeletal muscle biopsies from patients with hereditary and inflammatory myopathies, and to develop an integral coefficient to aid in the differential diagnosis of these conditions.

Material And Methods: The material is represented by biopsy specimens of m. tibialis anterior, m.

[Novel prospects for early diagnosis of cognitive impairment using Eye-tracking technology].

Objective: Is to develop a method for comprehensive assessment of fixation eye movements in patients with cognitive impairment.

Material And Methods: The study uses the Pupil Invisible eye-tracker. Using the PsychoPy software, a sequence of visual stimuli with audio and text accompaniment was created.

[Sleep disorders in patients with Lewy body dementia and Parkinson's disease].

article discusses the features of sleep disorders in patients with Lewy body dementia and Parkinson's disease. The focus is on behavioral disorders during the rapid eye movement phase, which are manifested by active movements and aggressive sleep behavior, as well as other sleep disorders, such as insomnia and excessive daytime sleepiness. The mechanisms of development of these disorders and their impact on the quality of life of patients and their relatives are described.

[A comprehensive study of Alzheimer's disease biomarkers in plasma and cerebrospinal fluid].

Objective: To determine, evaluate, and analyze the diagnostic value of various laboratory biomarkers of Alzheimer's disease (AD) in blood and cerebrospinal fluid (CSF).

Material And Methods: The concentrations of 93 potential biomarkers in plasma and CSF were studied in patients with AD at various stages (=53) and independently in the group at the predementia stage (=15).

Results: Statistically significant correlations of various directions (≤0.

Development of Immunochemical Systems for Detection of Human Skeletal Troponin I Isoforms.

Troponin I (TnI), together with troponin T (TnT) and troponin C (TnC), forms the troponin complex, a thin filament protein of the striated muscle that plays a key role in regulation of muscle contraction. In humans, TnI is represented by three isoforms: cardiac, which is synthesized only in myocardium, and fast and slow skeletal, which are synthesized in fast- and slow-twitch muscle fibers, respectively. Skeletal TnI isoforms could be used as biomarkers of skeletal muscle damage of various etiologies, including mechanical trauma, myopathies, muscle atrophy (sarcopenia), and rhabdomyolysis.