[Comparative study of the efficacy and safety of combined therapy with lornoxicam (Xefokam Rapid) and a nucleotide complex Xefomielyn in patients with exacerbation of chronic nonspecific low back pain].

Objective: To evaluate the efficacy and safety of combined therapy with lornoxicam (Xefokam Rapid) and a nucleotide complex Xefomielyn compared to lornoxicam monotherapy in patients with exacerbation of chronic nonspecific low back pain (CNLBP).

Material And Methods: The study included 181 patients divided into a monotherapy group Xefokam Rapid and a combined therapy group with the addition of the nucleotide complex Xefomielyn. Pain intensity was assessed using the Numerical Rating Scale, functional status using the Roland-Morris Disability Questionnaire, recurrence rate, and treatment satisfaction.

[Sleep disorders in patients with Lewy body dementia and Parkinson's disease].

article discusses the features of sleep disorders in patients with Lewy body dementia and Parkinson's disease. The focus is on behavioral disorders during the rapid eye movement phase, which are manifested by active movements and aggressive sleep behavior, as well as other sleep disorders, such as insomnia and excessive daytime sleepiness. The mechanisms of development of these disorders and their impact on the quality of life of patients and their relatives are described.

[Assessment of the significance of dilated perivascular spaces and nocture arterial hypertension in the development of Alzheimer's disease].

Objective: To study the severity and localization of dilated perivascular spaces (DPVS), the levels of protein markers of amyloidosis and neurodegeneration in the cerebrospinal fluid (CSF) at different daily blood pressure (BP) profiles in patients with Alzheimer's disease (AD) and other types of cognitive impairment.

Material And Methods: A total of 119 people, aged 53 to 92 years, including 55 patients with AD, 27 patients with vascular cognitive disorders (VCD), 19 patients with frontotemporal degeneration (FTD). All patients underwent BP monitoring for 24 hours using a standard oscillometric measurement method, lumbar puncture to assess A-42 and A-40 amyloid protein, total and phosphorylated tau protein in the CSF, magnetic resonance imaging tomography of the brain with subsequent assessment of the severity of expansion and localization of DPVS according to the G.

[Comparative characteristics of neuropsychological and neurometabolic changes in patients with Alzheimer's disease and vascular cognitive impairment].

Objective: To investigate the pattern and connections of neuropsychological and metabolic indices in patients with cognitive disorders of Alzheimer's and vascular (subcortical-cortical) types of different severity.

Material And Methods: A total of 177 patients were examined, including 85 patients with Alzheimer's disease (AD) and 92 patients with vascular cognitive impairment (VCI). All patients underwent complex neuropsychological examination; F-FDG PET was performed in 17 patients with AD and 15 patients with VCI.

[Traumatic brain injury as risk factor of Alzheimer's disease and possibilities of pathogenetic therapy].

The article examines the potential role of brain mechanical damage as a trigger for the development of neurodegenerative changes. Attention is paid to dysfunction of the neurovascular unit, and disruption of the functional and compensatory capabilities of blood flow. The importance of microhemorrhages that occur in the acute period of injury and the formation of first focal and then diffuse neuroinflammation is emphasized.