Rhabdomyosarcoma in Pediatric Patients Under 2 Years: Clinical Features and Outcome.

Background: Rhabdomyosarcoma (RMS) typically responds well to a combination of treatments with favorable prognosis in children 1 to 9 years old. However, infants may fare worse due to receiving less aggressive local therapy for concerns about long-term effects of surgery/radiation. This study investigates the clinical characteristics, treatment approach, and survival outcomes of RMS in children under 2.

Comparative techno-economic optimization of microgrid configurations using hybrid battery-hydrogen storage: NEOM case study, Saudi Arabia.

Renewable energy systems are at the core of global efforts to reduce greenhouse gas (GHG) emissions and to combat climate change. Focusing on the role of energy storage in enhancing dependability and efficiency, this paper investigates the design and optimization of a completely sustainable hybrid energy system. Furthermore, hybrid storage systems have been used to evaluate their viability and cost-benefits.

Newly Diagnosed Celiac Disease in a Patient With a Body Mass Index of 50.8 kg/m.

Celiac disease (CD) was previously known to be seen in underweight individuals, with weight loss being one of the key symptoms; however, newer data today is starting to show that most adults with celiac disease are either normal weight, overweight or obese. Here we present a 52-year-old patient with a body mass index (BMI) of 50.8 kg/m who was diagnosed with biopsy-proven CD and her tissue transglutaminase immunoglobulin A level was 45.

Train-related injuries in a developing country setting: Epidemiology and management.

Unlabelled: Train-related injuries represent a significant yet underreported public health challenge in developing countries, particularly in sub-Saharan Africa, where contemporary data are scarce. This study characterizes the epidemiology, clinical presentation, and outcomes of train-related trauma at a South African Level I trauma center, with a focus on identifying predictors of severe outcomes and informing context-specific interventions for this high-risk population.

Method: A retrospective analysis was conducted on 63 patients presenting to Groote Schuur Hospital between April 2008 and June 2013.

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 T cells underlies distinct functional potential.

Persistent antigen stimulation promotes differentiation of exhausted CD8 T (T) cells. T cells are distinct from circulating memory T (T) cells but share many features with tissue-resident memory (T) cells established following infection resolution. CD8 T cells co-expressing residency- and exhaustion-associated molecules in chronic diseases often correlate with clinical outcomes.