Prognostic value of arterial spin-labeling perfusion in anoxic brain injury: A retrospective cohort study.

Background: Anoxic brain injury is a potentially lethal condition characterized by cerebral hypoperfusion and irreversible neuronal injury. Arterial spin-labeling (ASL) perfusion and diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) have been proposed as tools to detect cerebral ischemic changes and may aid in the assessment of anoxic injury.

Aim: To explore the relationship between regional ASL perfusion patterns and clinical outcomes following cardiac arrest.

An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter.

An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative hemodynamic perturbations compared with magnetic resonance imaging and ex vivo RV foam casts. Finite element analysis demonstrated the AT electric field was confined to RV blood volume.

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations.

To gain molecular and mechanistic insights into initiation of the RAS-RAF signaling cascade, we developed and used a combination of multiscale simulation and experimental approaches. The influence and impact of the membrane on RAS and RAF proteins is a factor we are just beginning to understand and appreciate in more detail. Molecular simulation is an ideal methodology to further study this complicated relationship between the membrane and associated proteins.

Contribution of sympathetic nervous system activation to endothelial ischemia reperfusion injury in healthy adults.

Ischemia-reperfusion injury (IRI) describes the phenomenon through which the restoration of blood flow following prolonged ischemia exacerbates tissue damage during reperfusion. IRI can be modeled by inducing 20-min arm ischemia followed by reperfusion. This model causes transient impairments in brachial artery flow mediated dilation (FMD); however, the contribution of the sympathetic nervous system to these reductions remains unknown.

Copper and Temperature Interactions Induce Differential Physiological and Metal Exclusion Responses in the Model Brown Macroalga .

The toxic effects of copper (Cu) excess in brown macroalgae have been well characterized. However, the interactive effects of increased temperatures, associated with climate change, and Cu stress on these macrophytes remain almost unexplored. In this study, we exposed the model brown seaweed to different Cu concentrations (0, 0.