Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond.

Poly (ADP-ribose) polymerase (PARP) inhibitors have appeared as a transformative class of anticancer agents, particularly for tumors with homologous recombination deficiencies such as BRCA1/2-mutated breast, ovarian, prostate, and pancreatic cancers. Despite their clinical success, challenges such as poor bioavailability, systemic toxicity, and acquired resistance have limited their broader application. Nanotechnology-based drug delivery systems offer a promising strategy to overcome these limitations by enhancing the solubility, stability, and tumor-specific accumulation of PARP inhibitors while reducing off-target effects.

The biomedical frontier of fucoidan and laminarin: emerging insights.

Laminarin and fucoidan, two marine-derived polysaccharides, have garnered attention in biomedical research due to their unique bioactive properties. Laminarin, a β-glucan composed of glucose linked by β-1,3 and β-1,6 glycosidic bonds, and fucoidan, a sulfated polysaccharide, both demonstrate strong biocompatibility, low toxicity, and the ability to modulate cellular behaviors, making them promising candidates for various therapeutic applications. Recent research highlights their roles in tissue engineering, wound healing, drug delivery, and oncology.

Chitosan nanoparticles: a versatile frontier in drug delivery and wound healing across multiple routes.

The domain of nanoscience has observed significant advancements over the former two decades. Researchers in nanomedicine field have been rigorously exploring the employment of natural biodegradable polymers for targeted drug delivery (TDD). Chitosan (CS), acquired from the deacetylation of chitin, is a naturally occurring amino polysaccharide, whose features of non-toxicity, prolonged retention time, biocompatibility, increased bioavailability, and biodegradability have hastened extensive study into diverse applications.

Under the coconut palm - a retrospective analysis of trauma incidents caused by falling coconuts presenting to emergency department at a tertiary care centre in coastal India.

Background: Injuries due to falling coconuts are a common yet underreported form of trauma in the tropical regions. Although these might appear insignificant at first glance, the physical forces involved are potentially fatal. Despite their global prevalence, research on this subject remains scarce, making it a neglected public health concern.

Microbial consortia-derived cellulose biomaterial: Synthesis, characterization, and utility in neural tissue regeneration.

Therapeutic application of bacterial cellulose, a polymer produced by fermentative growth of bacteria, is often challenged by low yields and absence of high yielding strains. The current study reports the synthesis and characterization of bacterial cellulose from a novel microbial consortium of Weissela confusa, Neobacillus drentensis, and Bacillus sp. isolated from mother of vinegar and identified by 16S rDNA typing.