Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.

Human B cell immunity to the influenza hemagglutinin (HA) stem, a universal vaccine target, is often stereotyped and immunogenetically restricted, posing hurdles to study outside of humans. Here, we show that cynomolgus macaques vaccinated with an HA stem immunogen elicit humanlike public B cell lineages targeting two major conserved sites of vulnerability, the central stem and anchor epitopes. Central stem antibodies were predominantly derived from V1-138, the macaque homolog of human V1-69, a V gene preferentially used in human central stem broadly neutralizing antibodies (bnAbs).

Effects of site elevation and grazing exclusion on phenolic compound production in Nardus stricta plants in high-elevation grasslands.

Specialized plant metabolism, particularly phenolic compound production, contributes significantly to the functioning and resilience of mountain ecosystems. Livestock grazing can influence phenolic production, with its effects varying depending on microclimatic factors and soil conditions. Despite the ecological significance of this process, the impact of livestock grazing on phenolic production in alpine plants remains insufficiently explored.

The Role of Human Papillomavirus Genotypes on Anal Squamous Intraepithelial Lesions Among Gay, Bisexual and Other Men Who Have Sex With Men Living With HIV: Beyond HPV-16.

Persistent high-risk human papillomavirus (hHPV) infection, especially HPV-16, plays a central role in the development of high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the performance of co-testing (cytology and hHPV detection) in a real-world cohort of men who have sex with men (MSM) and transgender women (TW) living with HIV. We conducted a prospective study (2017-2023) at a tertiary care center in Spain.

[Landau-Kleffner Syndrome and Continuous Spike-and-Wave During Sleep Syndrome: Comparison of Clinical, Neurophysiological, and Neuropsychological Characteristics].

Introduction: Landau-Kleffner Syndrome (LKS) is a subtype of epileptic encephalopathy with spike-wave activation during sleep (EESWAS), characterized by acquired aphasia associated with the emergence of epileptiform abnormalities.

Patients And Methods: A cross-sectional descriptive study was conducted in a tertiary hospital, involving one group of children with LKS and another with EESWAS. The aim was to compare the clinical, neurophysiological, and neuropsychological aspects of both groups.

Assessment of Preferred Interview Format Among 2025 Urology Residency Match Applicants.

Objective: The Society of Academic Urologists (SAU) made no definitive recommendation on interview format for the 2025 urology match. The purpose of this study was to survey applicants for this cycle regarding preferences and perceptions related to interview format.

Methods: As part of a prospective assessment, surveys were administered to all applicants to our urology residency program for the 2025 cycle, both before interview and following the match process.