Publications by authors named "A A Demidov"

The Arctic warming leads to a decline in sea-ice extent and thickness, rapid warming and freshening of the sea surface which impact the distribution of phytoplankton size composition. Picophytoplankton is an ecologically important component of Arctic pelagic marine ecosystems, and its role may be altered by global warming. In this study, the abundance and biomass, the chlorophyll a (Chl-a) and primary production (PP) of picophytoplankton, and its spatial and temporal distribution were investigated in the Kara Sea during the ice-melt season in July 2019.

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Article Synopsis
  • Identifying cryptic pockets in proteins can reveal hidden binding sites, offering new avenues for drug development, particularly in challenging targets such as KRAS, which was thought to be "undruggable."
  • The discovery of the Switch-II cryptic pocket in the KRAS mutant has led to FDA-approved cancer treatments, highlighting the clinical relevance of these pockets.
  • A novel approach using weighted ensemble molecular dynamics simulations was employed to explore these cryptic pockets in KRAS, analyzing over 400 microseconds of simulations and validating the method's ability to predict binding sites while examining the mechanics of ligand interactions.
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Ongoing warming is leading to the accelerated shrinkage of glaciers located on Arctic islands. Consequently, the influence of glacial meltwater on phytoplankton primary production in Arctic bays becomes critically important in an era of warming. This work studies the spatiotemporal variation of primary production and chlorophyll a concentration in the bays along the eastern coast of the Novaya Zemlya archipelago.

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Property damage from wildfires occurs from spread into built-up areas, the wildland-urban interface. Fire spread occurs as embers from one burning structure ignite neighboring ones-but mitigation reduces the chances that fire spreads. In this study, we use a simulation model with realistic parameters for a neighborhood in California to illustrate patterns of marginal benefit from mitigation.

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Prior studies have reported that women outperform men in nonverbal communication, including the recognition of emotions through static facial expressions. In this experimental study, we investigated sex differences in the estimation of states of happiness, anger, fear, and disgust through static photographs using a two-culture approach. This study was conducted among the Tuvans and Mongolian people from Southern Siberia.

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