Copy Number Variation in the Amylase Gene () in the Brown Bear (), Based on Whole Genome Resequencing Data.

Copy number variation (CNV) in gene loci in animals can be driven by adaption to the environment. The relationship between CNV in genes for amylase (), which hydrolyzes starch, and dietary adaptation has been well studied. Copy number (CN) of is higher in human populations with high-starch diets, compared with those with low-starch diets.

Magnetically stimulated transient creep processes in a heterogeneous aluminum alloy with ferromagnetic inclusions.

This study analyzes the creep processes of a heterogeneous aluminum alloy containing ferromagnetic inclusions with an average size of 3-5 μm, and the influence of preliminary magnetic exposure (in a constant magnetic field (MF) with induction B < 0.75 T) on these processes. Experimental investigations were carried out to determine the characteristic times of the transient stages of short-term creep, which do not exceed approximately 25 ms.

Characterizing Microbial Communities in >7000- and >180,000-Year-Old Antarctic Permafrost Using a Low-Biomass Decontamination Protocol.

The McMurdo Dry Valleys may harbor diverse surface microbial communities, yet little is known about subsurface microorganisms in permafrost and their potential for paleoecological reconstruction. Here, we present microbial diversity and paleoecology from lower Wright Valley (7000- to 25,000-year-old) and Pearse Valley (>180,000-year-old) permafrost habitats in the McMurdo Dry Valleys. Using a new decontamination protocol, low-biomass extraction approaches, and 16S ribosomal RNA gene amplification sequencing, we assessed microbial community structure and diversity.

α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons.

One of the major histopathological features of Parkinsons's disease - intracellular Lewy bodies - consists of misfolded α-synuclein. This protein can self-assemble, spread through the brain and seed its own aggregation. Aggregated α-synuclein is shown to induce mitochondrial dysfunction that leads to neuronal loss.

The Compensatory Mechanisms in The Course of the Diastolic Dysfunction Development at Stress Cardio-myopathy.

Aim     To study the activation sequence of compensatory mechanisms during the development of diastolic dysfunction.Material and methods            The study was performed on rats with stress cardiomyopathy induced by high doses of isoproterenol (120 mg/kg twice a day). Heart function was studied 3-5 and 8-10 days after the injection by echocardiography and left ventricular (LV) catheterization.