Longitudinal investigation of psychological outcomes associated with screen use in Danish preschool children: study protocol for The Digital Child.

Introduction: Despite an increasing use of screens among preschool children and evidence suggesting potential adverse effects, there is a paucity of longitudinal research that aims to disentangle the multifaceted components of screen use and their unique associations with development. We present a protocol for a large-scale national longitudinal study with repeated measurements in Danish preschool children, with the aim of investigating the cross-sectional and cross-lagged longitudinal associations between screen use and psychological outcomes.

Methods And Analysis: The Digital Child Study is a national prospective observational cohort of Danish preschool children.

Serogroup W invasive meningococcal disease outbreak in Qatar following travel to Umrah.

Invasive meningococcal disease (IMD) is associated with significant morbidity and mortality in all age groups. Globally, reported cases predominantly belong to serogroups A, B, and C. Although serogroup W is less prevalent with regional distribution, it demonstrates shifting epidemiology linked to travel.

Young adult grandchildren's intergenerational and digital solidarity with grandparents and depressive symptoms during the pandemic.

Objective: We aimed to investigate the patterns of intergenerational and digital solidarity between young adult grandchildren and their grandparents, and how different patterns were associated with young adult grandchildren's depressive symptoms during the COVID-19 pandemic.

Background: It is known that a close bond between grandparents and young adult grandchildren positively influences young adult grandchildren's mental health. However, there is limited understanding of which patterns of relationships offer psychological benefits during the COVID-19 pandemic.

Vulnerability analysis and sustainable rehabilitation strategies for mangrove ecosystems in Bedono coastal area, Central Java.

Mangrove ecosystems in Bedono Village, Demak Regency, Central Java, are seriously degraded due to aggressive coastal abrasion, extreme soil salinity (45‰-80‰), and failure of previous rehabilitation programmes. This study aims to assess the level of vulnerability of mangrove habitat and formulate an integrated rehabilitation strategy that includes ecological and institutional aspects. Data were collected through tidal analysis, measurement of sediment texture and soil salinity, identification of plankton and macrobenthos diversity, and analysis of mangrove species community structure.

Monoallelic variants in ACVR1 in a cohort of Egyptian individuals with fibrodysplasia ossificans progressiva.

Objectives: Fibrodysplasia ossificans progressiva (FOP) is a rare ectopic ossification disorder of connective tissue deposited in the muscles, fascia, tendons, and ligaments. The disease is an autosomal dominant pattern caused by pathogenic variants of ACVR1. Herein, we describe the largest number of affected individuals from the Middle East North Africa region who presented with FOP.

Aromatic Volatile Compounds of Essential Oils: Distribution, Chemical Perspective, Biological Activity, and Clinical Applications.

Volatile, or essential, oils are the principal odorous components of certain plant species and constitute aliphatic and aromatic compounds in the oils' natural mix. The aromatic compounds are present in significant proportions in the oils of several plant species, usually referred to as aromatic plants, and hence the aromatic essential oils. These aromatic classes of compounds are abundant in oils of cloves, thyme, wintergreen, etc.

Integrated , microarray, and network pharmacology analysis reveals the multi-target anti-diabetic potential of .

Introduction: Diabetes mellitus (DM), particularly type 2 DM (T2DM), is a chronic metabolic disorder requiring novel therapeutic approaches as the available therapies are not meeting the current challenges. This study investigates the anti-diabetic potential of Vigna unguiculata using a network pharmacology approach, supported by and analyses.

Methods: The plant was collected from Khyber Pakhtunkhwa, Pakistan, and subjected to hydroalcoholic extraction and fractionation.

Parental counselling and autopsy results: A retrospective diagnostic cohort study at a multidisciplinary fetal neurology clinic.

Aim: To examine the accuracy of prenatal counselling at a multidisciplinary fetal neurology clinic (FNC) that led to termination of pregnancy (TOP), to improve the quality of future consultations.

Method: This retrospective diagnostic cohort study compared the imaging (neurosonography and intrauterine magnetic resonance imaging) of fetuses evaluated at our FNC between 2009 and 2019, which underwent TOP because of brain anomalies, to the autopsy reports for concordance. The degrees of concordance were full, partial, and discordant.

Aaptamine, Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers, Isolated from the Bunaken National Park's Sponge, Aaptos sp.

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising discovery of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp.

Detection of lumpy skin disease (LSD) virus and distribution of blood-sucking insects as potential vector in Indonesia.

Lumpy Skin Disease (LSD), caused by a virus from the Poxviridae family, is a significant disease in cattle and buffalo. First reported in Indonesia in February 2022 in Riau Province, LSD has raised concerns about its transmission. This research aims to identify potential vectors for LSD transmission as a foundation for vector control in smallholder cattle farms.

A case report of palmoplantar keratoderma in a 3-year-old girl: A structured approach in primary care settings.

Palmoplantar keratoderma (PPK) is a dermatological disorder characterised by excessive thickening of the palms and soles, encompassing more than 20 conditions. The disease is often misdiagnosed in primary care settings, leading to unnecessary treatments and delays. We present the case of a 3-year-old girl with skin thickening on both her palms and soles persisting for 2 years, initially believed to be an acquired condition.

AI-driven assessment of over-scanning in chest CT: A systematic review and meta-analysis.

Introduction: Scan range is crucial for CT acquisitions. However, irrelevant over-scanning in CT is common and contributes to a significant radiation dose. This review explores the role of artificial intelligence (AI) in addressing manual over-scanning in chest CT imaging.

Adjuvant radiation therapy in the management of nasal vestibule squamous cell carcinoma: a systematic review and meta-analysis.

Purpose: Nasal vestibule squamous cell carcinoma (NVSCC) is a rare malignancy, accounting for less than 1% of head and neck cancers. Its rarity and distinct anatomical location pose management challenges, with limited high-quality evidence guiding treatment. Early-stage NVSCC is often managed with surgery or radiation therapy (RT) alone, while advanced cases may benefit from surgical resection followed by adjuvant RT.

Navigating the shadows: the impact of mindfulness, cognitive fusion, and coping strategies on psychological distress among mental health workers in Timor Leste.

Background: Mental health workers in post-conflict settings such as Timor Leste face distinct stressors stemming from limited human resources, underdeveloped systems, and ongoing socio-political instability, all of which increase the risk of psychological distress among these professionals. Consequently, constructs such as mindfulness, cognitive fusion, and coping strategies are essential not only theoretically significant, but also serve as practical targets for strengthening mental resilience of these professionals in these high-burden environments. This study aims to investigate the relationships between mindfulness, cognitive fusion, coping strategies, and psychological distress (depression, anxiety, and stress) among mental health workers in Timor Leste.

Developing a pharmacist-led transition of care programme in the emergency department of a secondary care teaching hospital: a qualitative participatory co-design protocol.

Introduction: Transitions from the emergency department (ED) to home are high-risk periods for medication-related harm. Pharmacist-led interventions during this period may improve medication safety and care continuity, yet co-design approaches to develop such interventions remain underused. The aim of this study is to co-design a pharmacist-led transition of care programme for patients discharged from the ED.

Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial.

BackgroundMicrobiome manipulation research is focused on developing techniques to modify the gut microbiome and augment responses to immune checkpoint inhibitors (ICI). Fecal microbiota transplantation (FMT) represents a potential strategy to overcome primary or acquired resistance to ICI. 20 patients with advanced melanoma were enrolled in a phase I multicenter trial to evaluate the safety and response to anti-PD1 combined with FMT using healthy donor stool as first-line treatment (MIMic, NCT03772899).

From pathogenicity to therapy: Investigating the Therapeutic Potential of Bacillus anthracis Anthrax Toxin in Novel Cancer Therapies and Oncological Research.

Cancer continues to be a significant global health concern, with treatment alternatives that encompass radiotherapy, chemotherapy, surgical procedures, and novel methods utilizing bacterial toxins such as anthrax toxin. This review summarizes the significance, laboratory preparation, and application of anthrax toxin for targeting cancer cells, encompassing both basic and advanced scientific research. Additionally, between 2000 and 2025, we compiled several studies analyzing the impacts of different engineered anthrax toxins on various cancer models through an extensive review of biomedical databases.

Performance of Polystyrene-Impregnated and CCA-Preserved Tropical Woods Against Subterranean Termites in PNG Field and Treatment-Induced Color Change.

Logs supplied in Papua New Guinea and Indonesia are predominantly sourced from fast-growing tree species of plantation forests. The timber primarily consists of sapwood, which is highly susceptible to biodeterioration. At a training center, CCA (chromated copper arsenate) is still used for wood preservation, while in the wood industry, ACQ (alkaline copper quaternary) is commonly applied to enhance the service life of timber.

Advances in Molecular Diagnostics and Targeted Therapeutic Approaches in HER-2 Positive Breast Cancer.

Human epidermal growth factor receptor 2 (HER2) is linked with aggressive tumors in breast carcinoma patients and results in poor outcomes. HER2 signaling in breast cancer also interacts with phosphoinositide-3-kinase (PI3K)/Akt signaling route, mitogen-activated protein kinase (MAPK) pathways, and protein kinase C (PKC) activation. Hence, the diagnosis of HER2-positive status and targeting of HER2 in breast cancers is of vital importance as it forms the basis for trastuzumab therapy.

NCAM2 promotes targeting of APP from the cell surface to BACE1-containing recycling endosomes.

Convergence of amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1) in endosomes initiates the production of amyloid-β (Aβ) peptides that accumulate in brains of Alzheimer's disease patients. APP and BACE1 are segregated in neurons, and mechanisms triggering their convergence have remained poorly understood, limiting therapeutic attempts to reduce Aβ production. Neural cell adhesion molecule 2 (NCAM2) is a cell surface localized protein, which increases Aβ levels via mechanisms that are not known.

Redefining Digital Dentistry: Multidisciplinary Applications of 3D Printing for Personalized Dental Care.

The integration of 3D printing into dentistry has led to a revolution in the precision and personalization of dental care. This review examines the extensive applications of 3D printing technology in various branches of dentistry. With the capability to create highly detailed, patient-specific models, devices, and appliances, 3D printing is transforming clinical workflows, enhancing the accuracy of treatments, and reducing procedural time.

The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species.

Cell adhesion molecules (CAMs) are cell-surface-localized proteins mediating interactions of cells with other cells and the extracellular matrix. CAMs influence cell behavior and survival by inducing various intracellular signaling cascades that regulate diverse cellular processes including cytoskeleton remodeling and gene expression. Here, we review the evidence demonstrating that the levels, subcellular distribution, and binding affinities of CAMs of several major families including integrins, cadherins, immunoglobulin superfamily, and selectins are regulated by intracellularly generated or extracellular reactive oxygen species (ROS).

Does Community Spine X-Ray Misinterpretation Contribute to Delays in Treatment for Adolescent Idiopathic Scoliosis Patients?

Background: A substantial proportion of adolescent idiopathic scoliosis (AIS) patients present late at initial visit. Before orthopaedic consultation, community radiology is frequently used. Results inform primary care physicians to determine when an orthopaedic referral is indicated and guide the triage decisions in tertiary care.

CNC machining data repository: Geometry, NC code & high-frequency energy consumption data for aluminum and plastic machining.

Data is often referred to as the ``oil of the future,'' playing a crucial role in various applications, including the training of machine learning models. In the field of manufacturing, high-quality datasets are essential for optimizing production processes, improving energy efficiency, and developing predictive maintenance strategies. This paper introduces a comprehensive CNC machining data repository that includes three key data categories: (1) product geometry data, (2) NC code data, and (3) high-frequency energy consumption data.

Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways.

Background: Sepsis is a prevalent ailment that significantly affects hospitalized individuals around the globe. It is characterized by uncontrolled inflammatory responses resulting in organ injury and leading to high morbidity and mortality. The liver, a vital organ, is affected by sepsis, resulting in liver dysfunction.