2 results match your criteria: "and Arthritis and Clinical Immunology Program[Affiliation]"
Peripheral Blood DNA Methylation-Based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biologic Specimens and Data From the Osteoarthritis Initiative and Johnston County Osteoarthritis Project.
Arthritis Rheumatol
January 2023
Division of Rheumatology, Immunology, and Allergy, Department of Internal Medicine, University of Oklahoma Health Sciences Center, and Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City.
Objective: The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is a key unmet need in OA clinical research. The objective of this study was to develop baseline peripheral blood epigenetic biomarker models to predict knee OA progression.
Methods: Genome-wide buffy coat DNA methylation patterns from 554 individuals from the Osteoarthritis Biomarkers Consortium (OABC) were determined using Illumina Infinium MethylationEPIC 850K arrays.
Alum, an aluminum-based adjuvant, induces Sjögren's syndrome-like disorder in mice.
Clin Exp Rheumatol
July 2014
Division of Nephrology, University of Virginia, Charlottesville, VA and Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Objectives: Adjuvant-induced innate immune responses have been suspected to play a role in the initiation of certain autoimmune disorders. This study investigates the role of alum, an aluminum-based adjuvant in the induction of Sjögren's syndrome-like disorder in mice.
Methods: Inbred, female New Zealand Mixed (NZM) 2758 strain of mice were injected with alum.