1,454 results match your criteria: "Wroclaw University of Technology[Affiliation]"

Inorganic halide perovskites have been the subject of intensive research for their unique properties. Most current research focuses on halide ion exchange to modify the luminescence band gap and optical features. They are obtained mainly in colloids or thin layers, resulting in small grains with a narrow distribution.

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In this work, we address the task of monitoring Powder Bed Fusion-Laser Beam processes for metal powders (PBF-LB/M). Two main contributions with practical merit are presented. First, we consider the comparison between a large deep neural network (VGG-19) and a small model consisting of, among others, four convolutional layers.

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Background: The NUDIX superfamily encompasses highly diverse enzymes involved in a plethora of biological functions such as mRNA metabolism, DNA repair, and lipid peroxidation. These hydrolases are found in all domains of life and show surprising versatility in terms of the substrates that they process. The knowledge about the diversity of fungal NUDIX proteins is fragmentary, being largely limited to a small number of characterized enzymes from yeasts.

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Purpose: In our work, we focused on the development of nanostructured lipid carriers (NLCs) loaded with dexibuprofen (DXI) and their application for cancer therapy by proposing the binding of phospholipids with this non-steroidal anti-inflammatory drug (NSAID) to obtain new delivery systems.

Methods: We successfully synthesized seven conjugates with good yields, four of which are new, and have not been previously published in the literature. The structures of the obtained conjugates were confirmed and comparative in vitro studies of their antiproliferative activity were conducted, along with molecular modeling to assess their therapeutic potential.

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Materials with an apatite structure were investigated in vitro in dental bone augmentation procedures. This scientific study aimed to compare nanosized hydroxyapatite (nHAp) and fluorapatite (nFAp) materials in the form of tablets in in vitro studies, including cytotoxicity assessment and fluoride release. The nHAp and nFAp nanosized materials were obtained using the microwave hydrothermal method.

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: Caries or iatrogenic thermal trauma of the teeth have a significant impact on the dental pulp structure connected with stimulation of angiogenesis and lymphangiogenesis. Therefore, the aim of the study was to identify the difference in the rate of heat dissipation by vessels present in the dental pulp. : Freshly extracted healthy ( = 10) and carious ( = 14) molars and premolars were cut on a diamond saw and subjected to active thermographic examination and then subjected to lymphoscintigraphy and X-ray examination.

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Article Synopsis
  • Organic raw materials are sustainable sources that can be efficiently used in industries through proper design of processes, equipment, and protocols.
  • Microbial communities act as biocatalysts, working alongside human teams to optimize these processes, mimicking natural bioprocesses and creating a more eco-friendly industry model.
  • The concept of "Finnoflag biorefinery" has been tested for producing valuable chemicals, energy, and organic fertilizers from food or forestry side streams, aiming for a 100% sustainable production system.
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Purpose: It is well known that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (IND) exhibits significant anticancer potential reported not only by in vitro and in vivo studies, but also in clinical trials. Despite promising results, IND is not widely used as an adjunctive agent in cancer therapy due to the occurrence of several gastrointestinal side effects, primarily after oral administration. Therefore, this study aimed to develop a nanosystem with reduced toxicity and risk of side effects for the delivery of IND for cancer treatment.

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Introduction: Since proper risk stratification in a growing population of patients with acute coronary syndrome (ACS) is challenging, a potential advantage of adding the elements of geriatric assessment to the commonly used Global Registry of Acute Coronary Events (GRACE) 2.0 scale in predicting the risk of 6‑month death requires investigation.

Patients And Methods: The study group included 196 patients aged at least 65 years (mean [SD], 74.

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  • The study focused on creating new halolactones with specific chemical groups and testing them for biotransformations using filamentous fungi.
  • Only halolactones with a gem-dimethyl group at the C-5 carbon underwent transformations, with different fungal strains performing hydrolytic dehalogenation and hydroxylation reactions.
  • The resultant compounds were assessed for antimicrobial activity, showing strong antifungal effects against certain yeast-like fungi and antimicrobial activity against multidrug-resistant MRSA strains.
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Lysophosphatidylcholines Enriched with and Palmitoleic Acid Regulate Insulin Secretion via GPR119 Receptor.

ACS Med Chem Lett

February 2024

Faculty of Biotechnology and Food Sciences, Institute of Molecular and Industrial Biotechnology, Lodz University of Technology, Stefanowskiego 2/22, 90-537 Lodz, Poland.

Article Synopsis
  • LPCs, particularly those with palmitoleic acid, show promise as agonists for GPCRs, which are significant in regulating diabetes and obesity.
  • Recent findings indicate that palmitoleic acid activates insulin secretion through different GPCR signaling pathways.
  • The study involves synthesizing LPCs with palmitoleic acid isomers and examining their effects on pancreatic β cell viability and GPCR activation, supplemented by molecular modeling for potential binding sites.
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  • The paper reviews existing research (1971-2022) on the effects of infrasound (IS) and low frequency noise (LFN) on human health, focusing on studies related to annoyance, cardiovascular issues, and sleep disorders.
  • It highlights epidemiological findings that link exposure to IS and LFN with negative health outcomes, emphasizing the importance of peer-reviewed literature in understanding these effects.
  • Special attention is given to recent studies on specific sources of IS and LFN, particularly from wind turbines, reflecting their growing presence and potential impact on communities.
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  • The study introduces a new chiral framework using 11-aminomefloquine to create bifunctional organocatalysts that show very high enantioselectivity (over 99% ee) in Michael additions and Friedel-Crafts reactions.
  • The catalysts are unique because they include a secondary amine group, which enhances hydrogen bonding in its protonated form, as confirmed by DFT calculations.
  • This innovation indicates that these organocatalysts could be useful for a wide range of chemical reactions.
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Article Synopsis
  • The paper reviews the effects of infrasound and low-frequency noise (LFN) on human health, focusing on literature from 1973 to 2022.
  • It examines issues such as infrasound perception, annoyance, cardiovascular impacts, and sleep disorders.
  • Special emphasis is placed on recent studies regarding infrasound sources, particularly from wind turbines.
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Road simulators enable accelerated durability tests under similar-to-real road conditions. However, the road simulator itself generates the signals with the appropriate strength and amplitude that is adequate to the response registered by the sensors during the real run. Therefore, there is a need for verification of the validity of the representation of vehicle runs on a road simulator in terms of the shape of the generated profile and possible sources of uncertainty.

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Advanced Heat Treatment of Pearlitic Rail Steel.

Materials (Basel)

September 2023

Faculty of Mechanical Engineering, Wrocław University of Technology, Ignacego Łukasiewicza 5, 50-371 Wrocław, Poland.

The aim of this research is a systematic investigation of heat treatments of 60E1 profile rails made of steel R350HT, which would ensure the properties required by the standard EN 16273. Additionally, it presents a concept of cooling rails on a semi-industrial station, which will make it possible to obtain the desired properties. The dilatometric tests have demonstrated that the optimal cooling rate is within the scope of 3 °C/s to 6 °C/s, when both the EN 16273 standard's hardness distribution and microstructure requirements are fulfilled.

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The Identity and Mineral Composition of Natural, Plant-Derived and Artificial Sweeteners.

Molecules

September 2023

Analytical Chemistry and Chemical Metallurgy Division, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland.

Article Synopsis
  • The study analyzed the mineral composition of natural and artificial food sweeteners to verify their authenticity and assess possible toxic element risks.
  • The concentration of twenty minerals was measured using ICP-OES after samples were prepared using a microwave-assisted technique.
  • Results showed variability in mineral profiles among sweeteners and detected harmful elements like cadmium and lead, highlighting the importance of quality testing for consumer safety.
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Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.

ACS Biomater Sci Eng

September 2023

Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland.

Article Synopsis
  • Novel tissue regeneration strategies for bone healing are being developed with focus on innovative biomaterials to reduce reliance on grafts.
  • Effective engineering technologies now create synthetic biomaterials that closely mimic natural bone, prioritizing biocompatibility.
  • The manuscript reviews various methods for integrating bioactive molecules with scaffolding materials to enhance bone regeneration, exploring options for sustained activity and controlled release.
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Semiconductor quantum dot molecules are considered promising candidates for quantum technological applications due to their wide tunability of optical properties and coverage of different energy scales associated with charge and spin physics. While previous works have studied the tunnel-coupling of the different excitonic charge complexes shared by the two quantum dots by conventional optical spectroscopy, we here report on the first demonstration of a coherently controlled interdot tunnel-coupling focusing on the quantum coherence of the optically active trion transitions. We employ ultrafast four-wave mixing spectroscopy to resonantly generate a quantum coherence in one trion complex, transfer it to and probe it in another trion configuration.

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Effect of nutritional status on psychological functioning and coping in patients with lung cancer.

Nutrition

May 2023

Department of Surgery, 4th Military Teaching Hospital, Wroclaw Medical University, Wroclaw, Poland; Department of Nursing and Obstetrics, Faculty of Health Science, Medical University, Wroclaw, Poland. Electronic address:

Article Synopsis
  • Lung cancer patients often face malnutrition, which can lead to negative impacts on survival, treatment response, and overall well-being.
  • The study analyzed 310 lung cancer patients, revealing that a significant percentage were at risk for malnutrition, with those affected showing poorer psychological coping strategies compared to those with better nutritional status.
  • Advanced cancer stages and negative coping mechanisms are strong predictors of malnutrition, suggesting that addressing nutrition may improve patient outcomes in lung cancer care.
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Objective: Rationale for the review in the context of what is already known about the evaluation of stress and displacement patterns using finite element analysis in the maxilla of patients with cleft palate after orthodontic intervention.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). The protocol for this systematic review was registered with PROSPERO (CRD42020177494).

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This paper presents an original method for the comminution of polymetallic nodules in a hydro-jet mill of our own design, having the water jet pressure in the range of 70-200 MPa. The best comminution results are ensured by equipping the mill with a water jet having a diameter d = 0.7 mm and a comminution-homogenization tube having a diameter d = 2.

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Article Synopsis
  • Transient spectroscopies help detect charge carriers in semiconducting devices, particularly from trapping centers and quantum wells in heterostructures.
  • A method is proposed to precisely evaluate the effective mass of electrons in quantum well heterostructures, using the infinite well model.
  • For the InGaAsN/GaAs quantum well structure, the effective mass for conduction band charges is 0.093 ± 0.006, and for valence band charges, it is 0.122 ± 0.018.
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Article Synopsis
  • Work standardization is a key strategy for enhancing occupational safety, productivity, and quality while also involving employees in improving work methods.
  • In the construction industry, there are unique challenges in selecting operations for standardization, leading to its limited use and resulting in higher accident rates compared to manufacturing.
  • The article introduces an SCF model specifically designed for the construction sector, which helps prioritize operations that should undergo standardization to enhance safety.
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The commercial graphite felt GFA 10 was subjected to an activation process with the use of CO at 900 °C for 35 and 70 min. Pristine and heat-treated materials were characterized using various methods: low-temperature N adsorption, SEM, and EDS. Voltammetric measurements of GFA samples (before and after activation) as the working electrode were carried out.

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