Synthesis and study of antibiofilm and antivirulence properties of flavonol analogues generated by palladium catalyzed ligand free Suzuki-Miyaura coupling against PAO1.

The Suzuki-Miyaura coupling is one of the ubiquitous method for the carbon-carbon bond-forming reactions in organic chemistry. Its popularity is due to its ability to undergo extensive coupling reactions to generate a broad range of biaryl motifs in a straightforward manner displaying a high level of functional group tolerance. A convenient and efficient synthetic route to arylate different substituted flavonols through the Suzuki-Miyaura cross-coupling reaction has been explained in this study.

Using KMeans Clustering to Evaluate and Alert for Deviations of Linac Photon Beam Parameters.

Objective: To analyse the daily measured Dosimetric Quality Assurance (QA) parameters of linear accelerator (linac) using Unsupervised Machine Learning (ML) Algorithm thereby evaluating the current machine status and to highlight the probable cause of the 'out-of-range' measured parameter.

Methods: Five Parameters measured using PTW QuickCheckwebline device in a linac is subjected to KMeans clustering technique.  The measured parameters comprise of Central Axis Dose (CAX), Beam Flatness, SymmetryLR, SymmetryGT and Beam Quality (BQF).

Molecular insight into renal cancer and latest therapeutic approaches to tackle it: an updated review.

Renal cell carcinoma (RCC) is one of the most lethal genitourinary cancers, with the highest mortality rate, and may remain undetected throughout its development. RCC can be sporadic or hereditary. Exploring the underlying genetic abnormalities in RCC will have important implications for understanding the origins of nonhereditary renal cancers.

Teff Grain-Based Functional Food for Prevention of Osteoporosis: Sensory Evaluation and Molecular Docking Approach.

Osteoporosis is a highly prevalent skeletal disorder, which is characterized by compromised bone strength predisposing to an increased risk of fracture. The medical approaches presently followed for the prevention and treatment are associated with several side effects. Thus, it becomes important to design alternatives that are safer, economical, and easy to use.

Phytomedicinal therapeutics for male infertility: critical insights and scientific updates.

Infertility is a significant cause of anxiety, depression, and social stigma among couples and families. In such cases, male reproductive factors contribute widely to the extent of 20-70%. Male infertility is a multifactorial disease with several complications contributing to its diagnosis.