Epidural blood patch for cerebrospinal fluid leak-induced subdural hematoma in a pediatric patient: illustrative case.

Background: Intracranial hypotension (IH) is a secondary headache syndrome that can result from spontaneous or iatrogenic CSF leaks. Subdural hematomas (SDHs) are a particularly dangerous sequela of IH. Although epidural blood patch (EBP) is a recognized treatment for IH, its use in pediatric patients with SDH as a solitary intervention has not been reported.

Evaluating the Effect of a Molecular Point-of-Care Test on Acute Respiratory Infections in General Practice: Protocol for a Cluster Randomized Trial.

Background: Acute respiratory infections (ARIs) are frequent reasons for medical consultations in general practice and can lead to unnecessary recontacts. Introducing new point-of-care (POC) polymerase chain reaction (PCR) diagnostic equipment may offer an attractive and efficient way of providing a more precise and exact microbial diagnosis. Successful uptake of POC PCR equipment could potentially lead to a reduction in recontacts with benefits for both staff and patients.

Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies.

Background And Objectives: Neuroimaging findings in immune effector cell-associated neurotoxicity syndrome (ICANS) have not been systematically described. We created the chimeric antigen receptor (CAR) T-cell Neurotoxicity Imaging Virtual Archive Library (CARNIVAL), a centralized imaging database for children and young adults receiving CAR T-cell therapy. Objectives of this study were to (1) characterize neuroimaging findings associated with ICANS and (2) determine whether specific ICANS-related neuroimaging findings are associated with individual neurologic symptoms.

Superior health-related physical fitness and well-being in 12-15-year-old Danish adolescents who are active in organized leisure-time sports - a cross-sectional study.

Background: Global reports indicate that less than 20% of 11-17-year-olds meet physical activity recommendations, and while organized sports participation increases the likelihood of meeting these guidelines, no other studies were found that examined the impact on well-being and physical fitness outcomes among Danish adolescents based on participation in leisure time sports.

Methods: The study employed a cross-sectional design, assessing cardiorespiratory fitness, fat percentage, and well-being, as well as several other health and fitness outcomes among 1,333 Danish adolescents (50% girls). Differences between participants in organized sports and non-participants, as well as between participants in different sport categories were assessed through ANCOVA analysis.

Assessing validity and costs of virtual diagnostics for sleep disorders: A feasibility study.

IntroductionThe use of digital solutions including patient-reported outcomes is limited to follow-up of patients with established diagnoses but is rarely used as first step of the diagnostic process substituting a personal contact with a health professional. We report on the diagnostic validity and cost per patient implications based on a feasibility study of a new virtual diagnostic service (VDS) for common neurological sleep disorders that, as a first step, involves the collection and automated analysis of self-reported digital patient data.MethodsThe VDS was established at the Odense University Hospital, Denmark.

Can immunotherapy prevent the progression of airway disease?

Purpose Of Review: The potential of allergen immunotherapy (AIT) to prevent allergic airway disease progression are demonstrated. Though not all patients benefit equally, there is limited research on which patients may benefit most.In this article, we focus on factors that may influence the risk of progression and their influence on the preventive effects of AIT, and whether some patients may benefit more than others may.

A Tactful Prompt: The Time is Right for .

Feelings have long run high between many autistic advocates and behavior analysts. The former often experience and perceive ABA as harmful and traumatic in its methods, and prejudicial and stigmatizing in its objectives, with some of the latter retorting that criticisms reflect misunderstandings of the science rather than areas of true concern. The result? A deep and contentious conceptual divide, leaving little room for dialogue or progress.

Ectopic adipose tissue in subsistence populations with minimal coronary disease, large left atria, and very low rates of atrial fibrillation.

Background: Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations.

Methods: We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.

Place Matters: Geographic Distribution of Abortion Fund Services.

Background: Where you live impacts your access to all forms of health care, but abortion in particular. In response to restrictions on abortion, communities have organized to support those seeking abortion care via abortion funds. This study documents the services provided by these organizations and examines how they have been shaped by local conditions.

Direct On-Analyte Fabrication of Au Nanoparticles for Substrate-Free SERS Detection of Micro and Nanoplastics.

Detection of micro- and nanoplastic particles at extremely low concentrations in complex matrices is a critical goal in environmental science and regulatory frameworks. Surface-enhanced Raman spectroscopy (SERS) offers unique advantages for detecting molecular species in such mixtures, relying solely on their characteristic fingerprints. However, its application for plastic particles has been constrained due to weak analyte-substrate interactions.

Plasma-Driven Decomposition of HAN-Based Ionic Liquids.

A nanosecond pulse transient plasma is employed to initiate and control the exothermic decomposition of ionic liquids, namely, a mixture of hydroxylammonium nitrate (HAN) and 1-ethyl-3-methylimidazolium ethyl sulfate [EMIM]/[EtSO], as well as some noncombustible ionic liquids. Here, the plasma is discharged in a cylindrical geometry with a coaxial center wire electrode. High voltage (20 kV) nanosecond pulses (20 ns) at various frequencies up to 10 kHz produce a plasma discharge in the ionic liquid that initiates its nonthermal decomposition.

Anti-Müllerian Hormone Levels Are Associated With Skeletal Maturity in Adolescent Girls: A Longitudinal Study.

Background And Aims: The role of anti-Müllerian hormone (AMH), a potential marker of the hypothalamic-pituitary-ovarian axis, is not well established in adolescent females. Typical epidemiologic studies use secondary sexual characteristics or chronological age as predictors for AMH. Skeletal maturity, an indicator of bone development, however, has not been examined in association with AMH in adolescent females.

Optimizing radiography education: Adapting curricula to evolving clinical practices in UAE healthcare.

Background: Despite population growth, the UAE is experiencing a decline in the utilization of plain radiography (X-ray) due to changes in clinical priorities and advancements in imaging technologies like CT and MRI. This decrease impacts medical education, creating a gap between training and practical application. Ensuring evidence-based justification for radiological procedures is crucial to prevent overutilization and strain of healthcare resources, highlighting the need for updated curricula.

From pediatrics to adult care - Experiences of transition among youth with a chronic medical condition: A meta-ethnography.

Background: Approximately 10-30 % of the youth (aged 15-24) have a diagnosed chronic medical condition. Effective transition from pediatric to adult care is thus essential for disease management. The growing interest in the transition of young people with chronic medical conditions has led to numerous international studies revealing diverse and often inadequate transition practices.

The Use of Antibiotics for Uncomplicated Urinary Tract Infections in Adult Women: Qualitative Findings From the SCOUT Trial.

Background: This paper focuses on women's subjective experiences with UTIs and antibiotic use. Uncomplicated urinary tract infections (UTI) are among the most common infections treated in primary care, however, there is limited evidence regarding the experiences and their antibiotic treatment preferences.

Objective: The aim of this study is to gather experiences, beliefs, and attitudes regarding the use of antibiotics and the participation in the clinical trial.

Cognitive and Global Morphometry Trajectories as Predictors of Youth Persistent Distressing Psychotic-Like Experiences.

Psychotic-like experiences (PLEs) may arise from genetic and environmental risk leading to worsening cognitive and morphometry metrics over time, which in turn lead to worsening PLEs. Analyses used three waves of unique longitudinal Adolescent Brain Cognitive Development Study data (ages 9-13) to test whether changes in cognition and global morphometry metrics attenuate associations between genetic and environmental risk with persistent distressing PLEs. Multigroup univariate latent growth models examined three waves of cognitive metrics and global morphometry separately for three PLE groups: persistent distressing PLEs (n=356), transient distressing PLEs (n=408), and low-level PLEs (n=7901).

Higher blood lipid levels after the transition to menopause in two forager-horticulturalist populations.

Background: Reproduction affects health and longevity among females across the life course. While significant focus has been devoted to the role of menarche, menopause remains understudied. Most menopause research is conducted in industrialized populations, where the risk of cardiovascular diseases increases progressively during the menopausal transition.

Effects of a pilot simulation training on interdisciplinary closed-loop communication and time to critical actions at an emergency centre in Burundi.

Introduction: Emergency medicine simulation is an effective training modality in both high and low resource settings. We describe the authors' experiences conducting a four-week interdisciplinary, , simulation training series at an emergency centre in Burundi.

Methods: Training emphasized effective closed loop communication, early airway, breathing, and circulation assessment, as well as time to vital signs, IV placement, and oxygen administration when appropriate.

Instantaneous Frequency: A New Functional Biomarker for Dynamic Brain Causal Networks.

Background: This study introduces instantaneous frequency (IF) analysis as a novel method for characterizing dynamic brain causal networks from functional magnetic resonance imaging blood-oxygen-level-dependent signals.

Methods: Effective connectivity, estimated using dynamic causal modeling, is analyzed to derive IF sequences, with the average IF across brain regions serving as a potential biomarker for global network oscillatory behavior.

Results: Analysis of data from the Alzheimer's Disease (AD) Neuroimaging Initiative, Open Access Series of Imaging Studies, and Human Connectome Project demonstrates the method's efficacy in distinguishing between clinical and demographic groups, such as cognitive decline stages (e.

Surgical Outcomes in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis-Related Liver Disease.

Patients with chronic liver disease have a higher surgical risk compared with those without. For patients with inflammatory bowel disease (IBD), literature has shown that earlier surgical intervention for those with severe IBD has led to better outcomes regarding mortality and remission. For patients who have both IBD and chronic liver disease, management can be complex.

Early Impact of Bariatric Surgery on Brain Functionality.

Obesity is a chronic inflammatory disease with an alarming number of cases recorded, becoming a global public health problem. Thus, an increasing number of eligible individuals choose to undergo metabolic and bariatric surgery (MBS), known for its effective results in weight reduction and improvement of metabolic conditions. Despite reversing the damage to the central nervous system caused by obesity, these procedures also present neuronal complications.

Towards a National Longitudinal Tracking Framework of Health Graduate Practice Locations.

Aims: Workforce maldistribution is a challenge to the equitable provision of healthcare in Australia. This Commentary details how a multi-university, large-scale, and growing data asset is positioned to contribute strategically and operationally to addressing national workforce priorities.

Context: The Nursing and Allied Health Graduate Outcome Tracking (NAHGOT) study is a prospective longitudinal research project with a commitment to nationwide geographical coverage.

KGG: Knowledge-Guided Graph Self-Supervised Learning to Enhance Molecular Property Predictions.

Molecular property prediction has become essential in accelerating advancements in drug discovery and materials science. Graph Neural Networks have recently demonstrated remarkable success in molecular representation learning; however, their broader adoption is impeded by two significant challenges: (1) data scarcity and constrained model generalization due to the expensive and time-consuming task of acquiring labeled data and (2) inadequate initial node and edge features that fail to incorporate comprehensive chemical domain knowledge, notably orbital information. To address these limitations, we introduce a Knowledge-Guided Graph (KGG) framework employing self-supervised learning to pretrain models using orbital-level features in order to mitigate reliance on extensive labeled data sets.