Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep.

Objective: The objective of this study was to investigate the effect of meloxicam on the pharmacokinetics of cefquinome in experimental endotoxemic sheep. In addition, the MIC of cefquinome was determined against Escherichia coli, Pasteurella multocida, Klebsiella pneumoniae, and Mannheimia haemolytica.

Methods: The study was carried out on six sheep in three periods according to a longitudinal pharmacokinetic design.

Evaluation of the effects of chitosan application and growing media on the adaptation process of fercal grape rootstock.

Background: In plant micropropagation, the adaptation phase represents one of the most critical limiting steps due to the high mortality rates commonly observed under ex-vitro conditions. The Fercal grapevine rootstock, characterized by its high adaptability to calcareous soils, holds significant potential for large-scale propagation. Therefore, evaluating strategies to improve survival during the transition from in vitro to ex-vitro environments is essential.

Pharmacokinetics of Tolfenamic Acid Administered Orally and Intravenously at Different Doses in Pekin Ducks ().

This study aimed to examine the pharmacokinetic changes in tolfenamic acid administered intravenously and orally to ducks at different doses (2, 4, and 8 mg/kg). Furthermore, the binding ratio to plasma proteins was assessed utilizing the ultrafiltration method. Eighteen male Pekin ducks were randomly assigned to three dosage groups (2, 4, and 8 mg/kg), with each group undergoing a trial in two phases: intravenous (IV) and oral administration.

Pharmacokinetics, plasma protein binding and bioavailability of Ketoprofen in Pekin ducks after different routes of administration.

1. Although the anti-inflammatory drug Ketoprofen has been used in ducks, there has been no research on its pharmacokinetics. This study examined the disposition kinetics and bioavailability of Ketoprofen in Pekin ducks after intravenous (IV), intramuscular (IM) and oral administration for the first time.

Evaluation of the effects of monosodium glutamate on the development of the cerebellum in chicken embryos.

Monosodium glutamate (MSG) is a globally used food additive in the modern diet. This study aimed to search the impact of varying doses of MSG administered on embryonic development of the cerebellum. A total of 410 fertilized chicken eggs were randomly assigned to five groups: an untreated control group, a vehicle control group, and groups receiving low-dose (0.

Analysis of the maxillary sinus volumes via CBCT in patients with unilateral and bilateral cleft palate and lip.

Background: Cleft lip and palate (CLP) is a congenital condition that affects the development of midfacial structures. This study aimed to compare the maxillary sinus volumes (MSV) in patients with unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP) to those of healthy controls using cone-beam computed tomography (CBCT).

Materials And Methods: A total of 90 patients were included, consisting of 30 individuals with UCLP, 30 with BCLP, and 30 healthy controls.

Pharmacokinetics of Levamisole After a Single 20 mg/kg Intravenous, Intramuscular, or Subcutaneous Dose in Chukar Partridges ( Alectoris chukar ).

The pharmacokinetic features of levamisole were assessed in chukar partridges ( Alectoris chukar ) following intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations. The investigation included nine male partridges and a crossover pharmacokinetic design. Levamisole was administered to partridges at a dose of 20 mg/kg via IV, IM, and SC routes.

Ketoprofen Pharmacokinetics in Goats Following Repeated Treatment Alone or in Combination With Cefquinome.

This work was aimed at investigating the pharmacokinetic changes after repeated administration of ketoprofen (3 mg/kg, IM, once a day for 5 days) to goats either alone or in combination with cefquinome (2 mg/kg, IM, once a day for 5 days). The study was carried out on six goats according to a balanced, open, two-phase, cross-pharmacokinetic design. The plasma ketoprofen concentrations were measured using HPLC-UV, and the pharmacokinetic data were estimated using a non-compartmental analysis.

Influence of Gd doping on CuSnGdS thin film solar cell.

The effect of the Gd/Sn composition ratio of CuSnGdS is examined. The films are fabricated on glass substrates in a sulfur atmosphere via the spin coating. The influence of the Gd/Sn composition ratio on the structural, morphological, optical, and electrical properties of the films is investigated using X-ray diffraction, FESEM, UV-Vis, and Hall effect.

Effect of Gender on the Pharmacokinetics of Meloxicam in Sheep.

The objective of this investigation was to ascertain the impact of gender on the pharmacokinetics of meloxicam in sheep. The research was carried out on six female and six male Romanov sheep. Meloxicam was administered intravenously to sheep at a dose of 1 mg/kg.

Selective recognition of fluoride as a CBRN toxic agent by a non-symmetric pillar[5]arene and Bodipy combination.

The CBRN (chemical, biological, radiological and nuclear) materials caused to serious health risks that the effective detection of these agents is very important. Macrocyclic fluorescent sensors based on Pillar[5]arene bearing multi Bodipy units have been designed for toxic agents in the CBRN area. The prepared non-symmetric Pillar[5]arene derivative (Pillar[5]-Bodipys) was characterized by NMR, elemental analysis, FT-IR and melting point methods.

Liraglutide as a novel therapeutic for overweight in canines: A clinical study.

Background: The overweight/obesity in dogs is defined as a condition of abnormal fat accumulation or, beyond that, a multifactorial condition involving excessive fat accumulation along with different factors (insufficient physical activity, genetics (breed), metabolism, the microbiome, etc.). Preclinical obesity conditions increases the risk of progressing to clinical obesity and developing obesity-associated diseases such as type 2 diabetes, cardiovascular disease, certain cancers, and mental disorders.

Biochemical and histopathological evaluation of rapid maxillary expansion in experimentally induced sinusitis: A controlled animal study.

Background: Rapid maxillary expansion (RME) is a commonly used orthopedic method in orthodontics that may influence upper airway physiology. However, its effects on inflammation in sinusitis have not been clearly identified. This study aimed to evaluate the impact of RME on experimentally induced sinusitis in rats using biochemical and histopathological markers.

Virulence genes of Pasteurella multocida cap B and its potential cross protection in mice.

Pasteurella multocida is a Gram-negative coccobacillus from the Pasteurellaceae family, commonly residing as a commensal organism in the respiratory tracts of healthy animals. However, it possesses multiple virulence factors and can cause severe respiratory diseases. This study aimed to characterize P.

Influence of Dexamethasone on the Plasma and Milk Disposition Kinetics of Danofloxacin in Lactating Sheep.

This study planned to evaluate the impact of low (0.1 mg/kg) and high (1 mg/kg) doses of dexamethasone on the plasma and milk distribution of danofloxacin (6 mg/kg) in sheep after intravenous administration. Utilizing a crossover pharmacokinetic design, the research was conducted on six lactating ewes, with blood and milk samples collected at 18 predetermined time points over a 48-h period.

Analysis of canine gene constraint identifies new variants for orofacial clefts and stature.

Dog breeding promotes within-group homogeneity through conformation to strict breed standards, while simultaneously driving between-group heterogeneity. There are over 350 recognized dog breeds that provide the foundation for investigating the genetic basis of phenotypic diversity. Typically, breed standard phenotypes such as stature, pelage, and craniofacial structure are analyzed through genetic association studies.

The impact of -infected larvae on the severity of babesiosis in sheep.

Ovine babesiosis, caused by , is a significant tick-borne disease affecting sheep globally, with severe economic implications for sheep farming, particularly in Türkiye. is transmitted exclusively by adult ticks, but the potential role of infected larval stages in modulating disease severity has remained unclear. This study investigated whether infestation with -infected larvae reduces the severity of babesiosis following subsequent exposure to infected adult ticks.

Validation and comparison of EvaGreen- and TaqMan-based real-time qRT-PCR for diagnosis of the black queen cell virus in the honey bees.

The black queen cell virus (BQCV) is a common agent that causes covert infection in hives and has a global distribution. In this study, TaqMan probe and EvaGreen (EG) dye-based real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays based on the amplification of coding senquences for the BQCV structural protein (SP) and the non-structural protein (NSP) were developed and validated for the detection of BQCV in adult bee and larvae/pupae. Additionally, the performances of commonly used EG and TaqMan chemicals for real-time qRT-PCR analyses were compared.

Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities.

In this article, a series of calix[4]arenes derivatized with isatin derivatives at the phenolic-O position were synthesized as potential theranostic molecules for antitumor therapy. The cytotoxic mechanism of action of the synthesized compounds was determined by Alamar Blue assay and flow cytometry using MCF-7, MDA-MB-231, DLD1, HeLa and A549 human cancer cell lines and their ability to penetrate into PNT1A healthy epithelial cells. To detect DNA damage, the Comet test was applied after the synthesized compounds interacted with the cells.

Factors influencing the prevalence of acute bee paralysis virus in Apis mellifera and insights into its phylogenetic relationships.

Acute bee paralysis virus (ABPV) is a notable pathogen frequently detected in managed honeybee (Apis mellifera) colonies. Although infections are often covert, they can lead to severe outcomes in the presence of Varroa destructor infestations. This study aims to evaluate the prevalence of ABPV and its correlation with a range of biotic and abiotic stressors in managed beehives located in the Central Anatolia and Mediterranean Regions of Türkiye during the spring-summer and autumn seasons of 2021.

Synthesis, Anticancer Activity, and Mitochondria-targeted Bioimaging Applications of Novel Fluorescent Calix [4]arenes-benzimidazole Derivatives.

Background: Calix[n]arenes have attracted great attention due to their biocompatibility and superior stability. When the necessary functional groups are attached to these compounds, they may have the potential to target tumor tissues. Benzimidazoles were among the anticancer drugs discovered in recent years.

A half-natural origin approach for anticancer and antioxidant activities using sporopollenin and pillar[5]arene macroring.

Sporopollenin is a natural biomacromolecule which can be found in the outer wall (exine) of spores or pollens that it can be performed with clever designing in a lot of innovative and scientific areas. In this paper, a novel sporopollenin reformed with a recently synthesized pillar[5]arene molecule were elucidated by FT-IR spectroscopy, TGA and SEM techniques. This study is the first report leading to a comprehensive investigation of the biological applications of a functionalized bio-microcapsule including antioxidant and anticancer properties.

Novel Findings on the SNP18 Sequence and Its Functional Analysis in Hygienic Behavior of Apis mellifera.

Hygienic behavior (HB) is a crucial biological mechanism in honeybees that is associated with disease resistance. This study aimed to investigate the effect of the SNP18 sequence and environmental factors on the HB of honey bees, using a total of 14 colonies and 148 bee samples from seven different bee breeds. Association analysis revealed that colonies with Italian hybrids (IH) or young queens statistically (p < 0.

Neuroprotective role of curcumin on the hippocampus against the oxidative stress and inflammation of streptozotocin-induced diabetes in rats.

In recent years, it has gained importance to determine the effects of diabetes on central nervous system complications. This study aimed to assess the neuroprotective properties of curcumin against neuronal damage in the rat hippocampus caused by diabetes. In accordance with this purpose, we investigated the effects of curcumin on oxidative/antioxidative parameters and pro-inflammatory cytokines in the hippocampal tissue of diabetic Wistar rats.