Theoretical study on the influence of OH group position on the free radical scavenging ability of tryptamine derivatives.

A density functional theory (DFT) study investigated the influence of hydroxyl (OH) groups on the free radical scavenging capacity of tryptamine derivatives (OH-TAs). Stable forms of OH-TAs were evaluated in both gaseous and aqueous environments. While neutral forms predominate in the gas phase, cationic forms (protonated at the NH group) are favored in aqueous solution.

Investigation of the free radical scavenging ability of l-tryptophan and its derivatives using experimental methods and quantum chemical calculations.

The free radical scavenging ability of l-tryptophan (LP) and 5-hydroxy-l-tryptophan (HLP) was evaluated using experimental and theoretical methods. The impact of antioxidant concentration on the scavenging of DPPH˙ and ABTS˙ free radicals was assessed for both compounds. The results indicated that HLP exhibited superior scavenging ability, with IC values of 31.

 (Gesneriaceae), a new species from central Vietnam.

, a new species of Gesneriaceae family discovered in Tay Giang District, Quang Nam Province, Central Vietnam, is here described and illustrated. The new species is diagnosed by the combination of its stem up to 2 m long, sericeous hairs on young stem, leaf petiole and adaxial mid-vein, sparsely and minutely serrate leaf margin, axillary inflorescence spreading along stem, sparsely long gland-tipped hairs on peduncle, pedicel, calyx, outside corolla and pistil, calyx 5-disparted from base, purplish white flower with purple stripes inside corolla tube, and dish-shaped stigma formed by 2 semi-orbicular lobes horizontally expanding. Distinct features of the new species and its morphologically closest congener, , are compared and discussed.

Binding of inhibitors to the monomeric and dimeric SARS-CoV-2 Mpro.

SARS-CoV-2 rapidly infects millions of people worldwide since December 2019. There is still no effective treatment for the virus, resulting in the death of more than one million patients. Inhibiting the activity of SARS-CoV-2 main protease (Mpro), 3C-like protease (3CLP), is able to block the viral replication and proliferation.