DigiNet: Optimizing personalized care for patients with stage IV non-small cell lung cancer (NSCLC) through a digitally connected provider network-analysis plan of a prospective multicenter cohort trial.

Purpose: The German sector-based healthcare system poses a major challenge to continuous patient monitoring and long-term follow-up, both essential for generating high-quality, longitudinal real-world data. The national Network for Genomic Medicine (nNGM) bridges the inpatient and outpatient care sectors to provide comprehensive molecular diagnostics and personalized treatment for non-small cell lung cancer (NSCLC) patients in Germany. Building on the established nNGM infrastructure, the DigiNet study aims to evaluate the impact of digitally integrated, personalized care on overall survival (OS) and the optimization of treatment pathways, compared to routine care.

Consensus on clinical outcome measures for lumbar spinal stenosis: recommendations from the ISSLS lumbar spinal stenosis taskforce.

Purpose: The purpose of this study was to determine through a Delphi process a list of outcomes measures for clinicians to use when assessing individuals with Lumbar Spinal Stenosis (LSS).

Methods: A three-phase Delphi process was conducted by the International Society for the Study of the Lumbar Spine (ISSLS) Lumbar Spinal Stenosis Taskforce, including two online surveys, two virtual meetings, and three in-person consensus meetings at the ISSLS annual conferences (2023-2025). Participants evaluated and ranked outcome measures for LSS, with final endorsement requiring > 66% agreement.

Evaluation of Perception of Photic Phenomena Through Diffractive Multifocal Intraocular Lens Designs by Its Virtual Implantation.

Purpose: To analyze the difference in objective and subjective photic phenomena following virtual implantation of three different presbyopia-correcting diffractive intraocular lens (IOL) designs.

Methods: The study was conducted at JENVIS Research Germany. A prospective cross-over and double-masked trial design was used.

Love as Bait: A Scoping Review and Crime Script Analysis of Online Romance Scams.

This study presents a scoping review and crime script analysis of the modus operandi of online romance scammers. Online romance scams are a form of fraud in which perpetrators fabricate online romantic relationships with victims, aiming to emotionally manipulate and, ultimately, financially exploit them. The review aims to synthesize existing research on how scammers operate and to develop a comprehensive crime script that can guide prevention and policy efforts.

Synergistic Enhancement of Osimertinib Efficacy in Non-small Cell Lung Cancer Cells Through Epigallocatechin-3-Gallate: Mechanistic Insights Into YAP/TEAD/CTGF Axis Inhibition.

Purpose: Combinatorial therapies are essential for treating advanced non-small cell lung cancer (NSCLC), particularly overcoming resistance to third-generation epidermal growth factor receptor (EGFR) like osimertinib (OSI). The Hippo signaling pathway, a critical regulator of cell proliferation, apoptosis, and tumor progression, is often dysregulated in NSCLC and contributes to chemo-resistance. This study investigated the potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, to overcome OSI resistance by modulating the Hippo signaling pathway, specifically through inhibition of the YAP-1 (Yes-associated protein)-TEAD (TEA domain transcription factor)-CTGF (connective tissue growth factor) axis.

Claims filed after perceived malpractice in management of acute appendicitis: An observational nationwide cohort study.

Background And Aims: Acute appendicitis is the most common surgical emergency worldwide. Obtaining a correct diagnosis and timely management can be challenging even in modern medicine. Hence, appendicitis is still considered a "high-risk" diagnosis for litigation and claims of malpractice.

HRV-Based Thresholds in Rowing: Validity and Reliability Assessment.

The concurrent validity of lactate thresholds (LT1, LT2) and between-day reliability data from the rowing-specific heart rate variability (HRV)-based thresholds (HRVT) were examined. Thus, 21 rowers (19.6 ± 2.

Photoinactivation of Planktonic Cutibacterium acnes subsp. elongatum: A Study on Wavelength-Dependent Effects.

Bacterial inflammatory skin conditions, especially those caused by Cutibacterium acnes (C. acnes), are among the most common skin diseases globally. While C.

Factors Influencing Clinical Trials of Herbal Medicinal Products - Using Ginger as Example.

Ginger () has a global use as a spice, an ingredient of beverages, food supplements (syn. dietary supplements), as well as herbal medicinal products. Since the last update of ginger in ESCOP Monographs in 2009 a significant number of papers concerning its bioactive constituents and clinical uses have been published.

Personalized Interactive Music Systems for Physical Activity and Exercise: Exploratory Systematic Review and Meta-Analysis.

Background: Personalized Interactive Music Systems (PIMSs) are emerging as promising devices for enhancing physical activity and exercise outcomes. By leveraging real-time data and adaptive technologies, PIMSs align musical features, such as tempo and genre, with users' physical activity patterns, including frequency and intensity, enhancing their overall experience.

Objective: This exploratory systematic review and meta-analysis evaluates the effectiveness of PIMSs across physical, psychophysical, and affective domains.

Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.

Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes, determining molecular recognition and multivalent binding via receptor clustering.

Accuracy of recording linear erosion using an unmanned aerial vehicle (UAV).

Soil erosion is an ongoing environmental problem. To address this issue, calibrated erosion models are used to forecast areas vulnerable to erosion and to determine appropriate preventive measures. Model calibrations are based on erosion data recorded using different techniques such as photogrammetry from an unmanned aerial vehicle (UAV).

Route to chaos in multi-species ecosystems.

We investigate species-rich mathematical models of ecosystems. While much of the existing literature focuses on the properties of equilibrium fixed-points, persistent dynamics (e.g.

Experiences of disrespect and abuse during childbirth in the World Health Organization European region: A mixed-method study among 22 countries.

Objective: Despite advancements in maternity quality care worldwide, mistreatment of women during childbirth persists. Currently, there is a gap of knowledge on the occurrence of disrespect and abuse during childbirth in the World Health Organization (WHO) European region.

Methods: Within the IMAgiNE EURO (Improving Maternal Newborn Care in the WHO European Region During COVID-19 Pandemic) study, women 18 years and older who gave birth in healthcare facilities in the WHO European region, were invited to complete an online validated questionnaire regarding quality of maternity care.

Educational Intervention "Open Conversation and Reflection" to Enhance Person-Centeredness in Acute Geriatric Wards: A Qualitative Study of Consequences and Processes.

Background: Person-centered supportive care for older persons with acute illness is much needed but not easily achieved.

Aims Of The Study: To uncover processes and consequences of an educational intervention in acute geriatric wards intended as an exposure experience.

Design: General inductive qualitative analysis was conducted on data from a four-step intervention: group coaching, an open conversation with a patient and family member (PT/FM), reflection on transcribed conversations with co-participant, and group peer reflection.

Crystallization and crystal morphology of polymers: A multiphase-field study.

In this paper, we introduce a coarse-grained model of polymer crystallization using a multiphase-field approach. The model combines a multiphase-field method, Nakamura's kinetic equation, and the equation of heat conduction for studying microstructural evolution of crystallization under isothermal and non-isothermal conditions. The multiphase-field method provides flexibility in adding any number of phases with different properties making the model effective in studying blends or composite materials.

How Healthcare Provider Characteristics Affect Their Attitudes and Skills in Involving Families in Caring for Small and Sick Newborns Throughout the Perinatal Period.

Introduction: Healthcare providers (HCPs) are essential in providing care and working with families with small and sick newborns throughout the perinatal care continuum. While clinical experience, education, and training influence HCPs' attitudes and skills regarding family involvement in care, the specific factors affecting Ghanaian HCPs remain unclear.

Objectives: To identify HCPs' characteristics that influence their attitudes and self-perceived practice skills toward involving families in the perinatal care continuum for small and sick newborns.

Simultaneous inactivation of antibiotic-resistant bacteria and degradation of antibiotic-resistant genes in alkalised human urine.

The coexistence of pharmaceuticals and microorganisms in source separated urine poses a risk for the development of antimicrobial resistance (AMR), especially when urine-based fertilizers are applied to soils. While prior studies have investigated pathogen inactivation in source-separated wastewater matrices, few have evaluated the simultaneous fate of antibiotic-resistant bacteria (ARBs) and their corresponding resistance genes (ARGs) in real urine matrices, particularly under alkaline conditions. Here, we studied the inactivation of β-lactamase-producing and vancomycin-resistant and the degradation of their respective ARGs ( and A) in alkalized, unhydrolyzed urine (pH 10.

Does the Experimenter Presence Affect Verbal Working Memory?

Recent studies showed that the presence of the experimenter hinders executive functions. Belletier and Camos (2018) extended these findings to working memory, reporting a detrimental effect of the experimenter presence only when participants performed an aloud concurrent articulation during maintenance. Under such a condition, participants likely relied on an attentional maintenance mechanism rather that an articulatory mechanism, supporting the account of a capture of attention by the social presence.

Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting.

Efforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior toward treatment approaches as well as potential side effects to the surrounding normal tissue. We established a reproducible cerebral organoid model of brain tumorigenesis in an autologous setting by overexpressing , a common oncogene in brain tumors. GFP/c-MYC cells were isolated from tumor organoids and used in two different approaches: GFP/c-MYC cells co-cultured with cerebral organoid slices or fused as spheres to whole organoids.

Improving the Conduct of Health-Related Research in Schools.

Background: Schools serve not only as centers of education but also as critical environments for social development and promoting health and well-being of children and adolescents. Conducting health-related research in school settings offers valuable opportunities to identify current health challenges and assess preventive and interventional strategies.

Analysis: Researchers face several challenges when conducting health-related research in schools, including communication barriers, complex coordination among relevant stakeholders, and limited resources.

Using a Blended Approach to Thematic Analysis: A Case Study on Fatherhood and Imprisonment.

Thematic analysis (TA) has become a prominent qualitative research method for identifying patterns in experiences, responses, narratives, and meanings in relation to a research question. In this paper, we provide researchers with an understanding of different approaches to TA and offer practical guidance on conducting a blended approach to TA, which combines the strengths of different TA approaches. Despite their prevalence in the literature, blended approaches to TA are rarely clearly illustrated in research publications.

Swiss national radon database: impact of building and environmental factors.

Since the 1980s, radon has been recognized as a public health concern in Switzerland and internationally. In an effort to more accurately estimate the number of lung cancer cases attributable to radon exposure, Swiss health authorities initiated the creation of radon measurements into a centralized national database. As of 2025, this database comprises approximately 300,000 measurements from 150,000 buildings across the country.

The distribution of groundwater uranium in Chintamani village, Karnataka, India.

Background: Chintamani village, Chikkaballapura district, Karnataka, India was found to possess high aquifer uranium concentrations. Geologically, Chintamani village is located on bedrock that is rich in elements like potassium (K) that naturally contain high levels of radioactive elements, such as uranium and thorium, due to the presence of alkali-feldspar granites and gneisses. Aquifer depletion has caused the concentration of these elements in groundwater to increase over time, posing a potential health hazard to the residents of Chintamani village.

The bio-transformation of green tea infusion with tannase enzymes produced by KMS2-2.

Unlabelled: Green tea is one of the most widely drunk beverages globally; It is made from the processed leaves of the green shrub . The background study focused on the contained catechins and their hydrolysis by tannase-producing KMS2-2 strains were investigated. Tannin acyl-hydrolase is an inducible enzyme extensively used in the food industry.