Synthesis and exploration of the synergistic antioxidant effect of two α-aminophosphonic acids and their molecular docking investigation.

This study aimed to evaluate the antioxidant synergistic effects of two synthesized α-aminophosphonic acids (HAP1 and HAP2). We generated these α-aminophosphonic acids via a modified Irani-Moedritzer reaction using microwave irradiation. Different spectroscopic techniques fully characterized all compounds, including FT-IR, H NMR, P NMR, and elemental analysis.

Sexual health in cancer care: a narrative review and position statement from the Italian Association of Medical Oncology (AIOM).

Background: Sexual dysfunction is often underestimated in cancer patients and survivors due to a lack of communication with health care providers and a common belief that it is an inevitable consequence of the disease and treatment. In recent years, with dramatically improved survival rates, increased attention has been paid to aspects of quality of life, particularly sexual health, which consists of physical, psychological, and emotional dimensions. A dedicated Associazione Italiana Oncologia Medica (AIOM) working group was built to provide an updated overview on this topic, including specific insights on prevalence, available therapies, and dedicated treatment paths.

Antifungal and Antibiofilm Activities of 2-Aminobenzoic Acid Derivatives Against a Clinical Ocular Isolate for Biomedical Applications.

Ocular fungal infections are slow-progressing conditions that primarily affect the cornea but can also involve the entire eyeball. is one of the most involved species. Both diagnosing and treating these infections require prompt and effective action.

The effect of biogenic amines in the neuromodulation of insect social behavior.

Interactions among colony members in insect societies involve a wide range of behaviors, including collective defense, recruitment, foraging, and parental care. Despite significant advances in research, our understanding of how variations in neuroanatomical structure and physiological conditions drive changes in behavior remains incomplete. This review examines the critical role of biogenic amines in modulating social behaviors in insects.

Regeneration responses of Ankaferd Blood Stopper, platelet-rich-plasma, andon sciatic nerve injury in the obese rats.

Obesity is a prevalent and potentially fatal disorder in industrialized nations, often due to an imbalance between calorie intake and energy expenditure. The study investigates the effects of Ankaferd Blood Stopper (ABS), platelet-rich plasma (PRP), and(MC) on obese rats with sciatic nerve injuries using stereological and electron microscopic techniques. Twenty-four female Sprague Dawley rats, aged 8-10 weeks, were divided into three groups: the obese gap ABS group (OGABS), the obese gap PRP group (OGPRP), and the obese gap MC group (OGMC).

Ultrasound-assisted green synthesis of silver nanoparticles using Ruta graveolens L. Extract and antitumor evaluation.

This study aims to evaluate the ultrasound-assisted synthesis of silver nanoparticles (AgNPs) based on an aqueous extract of Ruta graveolens L. to reduce Ag to Ag. In addition, the biological activity of the synthesized AgNPs was evaluated against tumor cells.

LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.

Longitudinal multi-view omics data offer unique insights into the temporal dynamics of individual-level physiology, which provides opportunities to advance personalized healthcare. However, the common occurrence of incomplete views makes extrapolation tasks difficult, and there is a lack of tailored methods for this critical issue. Here, we introduce LEOPARD, an innovative approach specifically designed to complete missing views in multi-timepoint omics data.

Diagnosis and Screening Strategies for Detection of Familial Hypercholesterolaemia in Children and Adolescents in Italy: A Survey from the LIPIGEN Paediatric Group.

Background: Awareness, diagnosis, and treatment of familial hypercholesterolemia (FH) starting from childhood are a cornerstone of cardiovascular disease prevention. The LIPIGEN Paediatric Group, a network of specialised centres for the diagnosis and management of familial genetic dyslipidemia, is an active part of this mission.

Materials And Methods: This is the second exploratory survey organised within the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) paediatric centres.

Optimizing Advance Care Planning in Dementia: Recommendations From a 33-Country Delphi Study.

Context: Advance care planning (ACP) is relevant yet challenging with cognitive decline.

Objective: To provide evidence and consensus-based clinical recommendations for how to conduct ACP in dementia.

Methods: International Delphi study conducted by the European Association for Palliative Care 'ACP in dementia' taskforce with four online surveys (September 2021-June 2022).

Atopic Dermatitis and Atopic Keratoconjunctivitis: New Insights in the Analyses of Microbiota and Probiotic Effect.

Atopy is defined as a predisposition to hypersensitivity reactions against a range of antigens. It is characterized by the activation of CD4+ T helper type 2 (Th2) cells and an increased production of immunoglobulin E (IgE). The most common atopic conditions are atopic dermatitis, asthma, allergic rhinitis, food allergies, and atopic ocular diseases.

PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose.

Beyond the regulation of cholesterol metabolism, a number of extrahepatic functions of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been increasingly identified. The main purpose of this study was to verify whether PCSK9 expression in vascular smooth muscle cells (VSMC) is influenced by insulin resistance and high glucose (HG). In cultured rat aortic VSMC from lean insulin-sensitive Zucker rats (LZRs) and obese insulin-resistant Zucker rats (OZRs), a classical animal model of insulin resistance, we evaluated PCSK9 expression with or without the monoclonal antibodies against PCSK9 Alirocumab and Evolocumab or the synthetic PCSK9-binding peptide PEP 2-8.

Highly-sensitive quantification of carbamazepine and identification of its degradation and metabolism products in human liver by high performance liquid chromatography - High resolution mass spectrometry.

A method for the qualitative and quantitative determination of carbamazepine in human liver tissues using high-performance liquid chromatography coupled with high-resolution mass spectrometry has been developed. Validation has been carried out and the main analytical characteristics of the developed method have been determined. The limit of detection (LOD) is 1 ng/g, and the lower limit of quantification (LLOQ) is 5 ng/g.

How do we transfuse children in Italy? Results of a national survey.

Background: Adherence to optimal practices in the preparation and issuance of pediatric blood components can significantly influence patient care outcomes. This study aims to examine the blood banking procedures across prominent Italian children's hospitals, with the goal of identifying both consistent and potentially divergent standards within this field.

Materials And Methods: A survey was conducted among the blood banks affiliated with the Italian Association of Pediatric Hospitals.

Comparison of Hospital Stay After Open Abdominal Aortic Aneurysm Repair With or Without Enhanced Recovery Protocol.

Objective: Enhanced recovery after surgery (ERAS) is a protocol of evidence based practices applied in major surgery. Open aortic aneurysm repair is major surgery in terms of complications and mortality. This study aimed to compare early outcomes of ERAS with a traditional post-operative protocol in patients undergoing elective open aortic surgery.

The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study.

Peripheral nerve injuries are commonly encountered in clinical practice. Peripheral nerve injuries most commonly result in serious problems affecting quality of life. The present study is designed to research the possible neuroprotective effects of Ankaferd blood stopper (ABS), platelet-rich plasma (PRP), and Momordica charantia (MC) on regeneration using unbiased stereological techniques.

A picit jeu: Agent-based modelling with serious gaming for a fire-resilient landscape.

Wildfire governance requires addressing driving physical, biological and socio-economic processes, by promoting the development of fire-resistant and resilient landscapes. These landscapes can best be achieved by strategies that integrate fuel management for direct prevention with allied socio-economic activities, through the collaboration of stakeholders with different and sometimes conflicting interests. This work aims to address the need for new approaches supporting the participatory process of collective decision-making, helping stakeholders explore land management strategies for landscape fire resilience.

Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus.

Background: The choroid plexus (ChP) is the secretory epithelial structure located in the brain ventricles. Choroid plexus tumors (CPTs) are rare neoplasms predominantly occurring in young patients with intensified malignancy in children. CPT treatment is hindered by insufficient knowledge of tumor pathology and the limited availability of valid models.

Strigolactones promote flowering by inducing the miR319-- module in tomato.

Strigolactones are a class of phytohormones with various functions in plant development, stress responses, and in the interaction with (micro)organisms in the rhizosphere. While their effects on vegetative development are well studied, little is known about their role in reproduction. We investigated the effects of genetic and chemical modification of strigolactone levels on the timing and intensity of flowering in tomato ( L.