Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults.

Background: Resistance exercise training is an effective treatment strategy to counteract the age-related loss of muscle mass and strength in older adults. However, there is a large inter-individual variation in muscle fiber hypertrophy following resistance exercise training. It has been hypothesized that a less than optimal muscle fiber capillarization and perfusion capacity may compromise muscle hypertrophy during resistance exercise training in older adults.

Muscle fiber type grouping does not change in response to prolonged resistance exercise training in healthy older men.

Background: Ageing of skeletal muscle is characterized in some by muscle fiber type grouping due to denervation-reinnervation cycles, but the severity of fiber type grouping varies widely across individuals of the same chronological age. It remains unknown whether fiber type grouping is associated with lower muscle mass and/or reduced physical function in elderly. Therefore, we assessed the relationship between fiber type grouping and indices of muscle mass and physical function in older adults.

Muscle fiber capillarization is associated with various indices of skeletal muscle mass in healthy, older men.

Introduction: Muscle fiber capillarization plays a fundamental role in the regulation of skeletal muscle mass maintenance. However, it remains unclear to what extent capillarization is related to various other skeletal muscle characteristics. In this study we determined whether muscle fiber capillarization is independently associated with measures of skeletal muscle mass, both on a whole-body and cellular level, and post-absorptive muscle protein synthesis rates in healthy older men.

Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults.

Introduction: Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle mass and strength gains one year after partaking in a successful RT program.

Methods: Fifty-three healthy older adults performed a 24-wk supervised RT program.

Leucine Supplementation Does Not Attenuate Skeletal Muscle Loss during Leg Immobilization in Healthy, Young Men.

Background: Short successive periods of physical inactivity occur throughout life and contribute considerably to the age-related loss of skeletal muscle mass. The maintenance of muscle mass during brief periods of disuse is required to prevent functional decline and maintain metabolic health.

Objective: To assess whether daily leucine supplementation during a short period of disuse can attenuate subsequent muscle loss in vivo in humans.