A presentation of brown tumor in a patient with parathyroid adenoma and end-stage renal disease: A case report.

Rationale: Brown tumor (osteitis fibrosa cystica) is a benign bone lesion associated with hyperparathyroidism that can affect multiple bones in patients with end-stage renal disease (ESRD).

Patient Concerns: We present the case of a 32-year-old female with ESRD on maintenance hemodialysis who experienced body aches, muscle weakness, constipation, and mood swings for 3 months.

Diagnoses: Initial tests revealed elevated parathyroid hormone (PTH), serum calcium, and phosphorus levels.

Recurrent Malignant Phyllodes Tumor of the Breast: A Case Report.

Malignant phyllodes tumors of the breast are rare fibroepithelial neoplasms with aggressive behavior and high recurrence rates. They pose significant diagnostic and therapeutic challenges due to their overlap with other malignancies, necessitating accurate diagnosis and a tailored treatment approach to improve patient outcomes. A 29-year-old Asian female initially underwent a lumpectomy for a right breast mass diagnosed as a phyllodes tumor on histopathology.

A Case of Idiopathic Chest Pain Following Watchman Device Placement.

Chest pain following left atrial appendage closure (LAAC) with the Watchman device is rare but can occur due to complications such as pericarditis or myocardial infarction. We present the case of a 59-year-old male with atrial fibrillation who developed sharp, left-sided chest pain exacerbated by inspiration after undergoing Watchman device placement. Despite extensive diagnostic evaluations, including electrocardiograms (ECGs), echocardiograms, and cardiac catheterization, the exact cause of the pain remained unclear, with no signs of acute coronary syndrome or pericardial effusion.

Emerging trends and disparities in mortality due to coexisting non-Hodgkin's lymphoma and respiratory infections: A U.S. nationwide retrospective analysis from 1999 to 2020.

Non-Hodgkin lymphoma (NHL) patients are highly susceptible to respiratory infections due to immunosuppression from both the disease and its treatments. Understanding mortality trends and disparities in this population is crucial for improving care and reducing the burden of coexisting conditions. This study analyzed death certificates from the Center of Disease Control Wide-Ranging Online Data for Epidemiologic Research database for individuals aged ≥ 25 years who died between 1999 and 2020 with both NHL and respiratory infections.

Aggressive basaloid squamous cell carcinoma of the lung in a young patient: a case report.

Introduction And Importance: Basaloid squamous cell carcinoma (BSQCC) of the lung is a rare and aggressive subtype of squamous cell carcinoma. It predominantly affects individuals over 60 with a history of tobacco use. This case report highlights the unique presentation of BSQCC in a young, non-smoking patient, emphasizing the need for early and accurate diagnosis.

Endoscopic evaluation of upper gastrointestinal bleeding in high-risk populations for hepatitis B and C: a cross-sectional study.

Objective: This cross-sectional study investigates the prevalence and clinical outcomes of upper gastrointestinal bleeding (UGIB) among patients at a tertiary care center. It focuses on esophageal varices and their association with hepatitis C and B infections.

Methods: A total of 383 patients aged 18 and above who presented with UGIB were included.

Jervell and Lange-Nielsen Syndrome (JLNS) in a 13-Year-Old Girl: A Rare Case Report.

JLNS is a rare genetic disorder characterized by congenital sensorineural hearing loss and a prolonged QTc interval, leading to life-threatening arrhythmias. Early diagnosis, beta-blocker therapy, lifestyle modifications, and consideration of ICD surgery are critical in managing sudden cardiac death risk.

Drug-Induced Renal Vasculitis: Etiology, Pathogenesis, Clinical Manifestations, and Therapeutic Approaches-A Narrative Review.

Background And Aims: Drug-induced renal vasculitis arises from various medications that cause immunological dysregulation or direct vascular damage, leading to inflammation and thrombosis. Clinical manifestations vary widely, from mild constitutional symptoms to severe organ dysfunction. This review aims to thoroughly explore drug-induced renal vasculitis, focusing on its etiology, pathological mechanisms, clinical manifestations, diagnostic challenges, and therapeutic approaches.

Cerebral venous sinus thrombosis in a postpartum woman: a case report on early diagnosis and management.

Introduction And Importance: Cerebral venous sinus thrombosis (CVST) is a rare but serious condition that can cause permanent neurological impairments if not promptly diagnosed and treated. Its nonspecific presentation, such as headache and altered awareness, often delays diagnosis. Postpartum women are at heightened risk for CVST, necessitating vigilance.

Merkel cell carcinoma in a patient with basal cell carcinoma: a case of localized disease with negative sentinel node biopsy.

Introduction: Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer with a high risk of recurrence and metastasis. It typically affects sun-exposed areas in elderly or immunocompromised individuals. Early diagnosis and management are essential due to its rapid progression and potential for early metastasis.

Dome osteotomy for cubitus varus correction in a 26-year-old male with left elbow gunstock deformation: a case report.

Background: Cubitus varus deformity is a common complication of untreated elbow fractures in children but is rare and challenging to treat in adults. This study presents the first documented case of correcting cubitus varus deformity in an adult.

Case Presentation: A 26-year-old male laborer presented with a deformed left elbow and impaired limb function due to a childhood fall.

Kikuchi-Fujimoto disease: an unusual case report of lymphadenopathy with the absence of classic symptoms.

Introduction And Importance: Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder in young adults, characterized by fever and cervical lymphadenopathy. Its uncertain etiology is associated with viral infections and autoimmune conditions, complicating diagnosis. Our patient had no significant past medical conditions, no history of known infections, prescription drug use, or autoimmune diseases within the family, reducing the likelihood of identifiable predisposing factors for KFD.

A rare case of necrotizing fasciitis secondary to a perforated appendix.

Introduction And Importance: Acute appendicitis is a common emergency, but its variable presentation can delay diagnosis and treatment, leading to severe complications. Necrotizing fasciitis, although rare, can arise as a life-threatening consequence of perforated appendicitis. Prompt recognition and intervention are crucial to prevent fatal outcomes.

Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass.

Introduction: Tailgut cysts, or retro-rectal cystic hamartomas, are rare congenital lesions arising from embryonic hindgut remnants, typically located in the retro-rectal area. These cysts present some diagnostic challenges due to vague symptoms and potential for malignancy.

Case Presentation: A 25-year-old female presented with a 5-year history of perianal swelling.

Multifactorial Etiology of Sertoli Cell-Only Syndrome: A Rare Case Report.

This rare case from Pakistan highlights the multifactorial etiology of Sertoli Cell Only Syndrome, emphasizing the importance of early identification and management of contributing factors such as trauma, varicocele, and surgical interventions to improve fertility outcomes.

Comparative efficacy and safety of tissue plasminogen activators (tPA) in acute ischemic stroke: A systematic review and network meta-analysis of randomized controlled trials.

Background: Intravenous alteplase (ALT) is the standard treatment for acute ischemic stroke (AIS). However, recent trials comparing other tissue plasminogen activators (tPAs) like tenecteplase (TNK) and reteplase with ALT have yielded conflicting results. This necessitated a network meta-analysis to compare the efficacy and safety of various tPAs in AIS patients.

Congenital Insensitivity to Pain and Anhidrosis With Orthopedic and Self-Injury Complications in a 5-Year-Old Boy: A Case Report.

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder because of NTRK1 gene mutations, leading to an inability to perceive pain and temperature and lack of sweating. Its rarity and unique clinical challenges, such as severe injuries from the inability to sense pain, make reporting cases critical. A 5-year-old boy, the third child of consanguineous parents, was referred for a fractured femur.

A Case of Recurrent Pemphigus Foliaceus Following Noncompliance to Medication.

Pemphigus foliaceus (PF) is a rare autoimmune blistering disorder requiring consistent immunosuppressive therapy for management. A 66-year-old male with a history of PF presented with worsening blisters and erosions after discontinuing medication. The patient had flaccid bullae and erosions on the face, scalp, chest, and back.

Neuropsychiatric manifestations of anti-N-methyl-D-aspartate receptor encephalitis in a 14-year-old female: A case report.

Key Clinical Message: This case underscores the critical importance of timely recognition and management of NMDAR encephalitis in adolescents to mitigate potential long-term sequelae. If a pediatric patient presents with suspected viral encephalitis, autoimmune etiology must be excluded via cerebrospinal fluid antibody assay to guide appropriate immunosuppressive therapy, and improve patient outcomes.

Abstract: Autoimmune encephalitis particularly involving the n-methyl-d-aspartate receptor (NMDAR) is recognized as a rare cause of acute encephalopathy in pediatric patients.

The Effects of Gestational Diabetes on Fetus: A Surveillance Study.

Introduction: Gestational diabetes is an intolerance to glucose diagnosed during pregnancy that goes away postpartum. Gestational diabetes may result in outcomes such as birth trauma, increased rates of cesarean sections, and macrosomia. This study aims to determine the outcomes of gestational diabetes mellitus (GDM) on maternal and fetal health in a tertiary care hospital setting.