Predictors of change in sleep disturbance in Canadian long-term care facilities: a longitudinal analysis based on interRAI assessments.

Purpose: Sleep disturbance is prevalent in long-term care facilities (LTCFs), yet there is limited understanding of individual factors predicting changes in sleep within these populations. Our objective was to determine predictors of sleep disturbance in LTCFs and investigate variation in prevalence across facilities in two Canadian provinces-New Brunswick and Saskatchewan.

Method: This retrospective longitudinal cohort study used interRAI comprehensive health assessment data from 2016 to 2021, encompassing 21,394 older adults aged ≥ 65 years across 228 LTCFs.

Factors facilitating or hindering the use of antibiotic-sparing treatment strategies in women with uncomplicated urinary tract infections: a scoping review.

Purpose: Antibiotic-sparing treatment (ASPT) strategies, such as delayed prescribing and symptomatic treatment, are promising to reduce antimicrobial consumption (AMC) in patients with uncomplicated urinary tract infections (uUTI). The aim of this scoping review was to identify literature reporting on factors that may act as barriers and facilitators to the use of ASPT in order to improve implementation.

Methods: MEDLINE (Ovid), Embase, the Cochrane Database, Google Scholar, Proquest Dissertations and Theses, the Clinical Trials Gov Registry and the ICTRP WHO Registry were searched for evidence of health care professionals and/or patients exposed to ASPT in the context of uUTI.

Biomechanical superiority of novel dynamic tape over standard tape suture in distal triceps tendon repair: a human cadaveric study testing an intense early rehabilitation protocol.

Background: Distal triceps tendon rupture is related to high complication rates with up to 25% failures. Elbow stiffness is another severe complication, as the traditional approach considers prolonged immobilization to ensure tendon healing. Recently, a dynamic tape was designed, implementing a silicone-infused core for braid shortening and preventing repair elongation during mobilization, thus maintaining constant tissue approximation.

Impact of diabetes on outcomes of patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease undergoing percutaneous coronary intervention.

Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.

Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.

A New Family of Ternary Intermetallic Compounds with Dualistic Atomic Ordering - The ZIP Phases.

A new family of nanostructured ternary intermetallic compounds - named the ZIP phases - is introduced in this work. The ZIP phases exhibit dualistic atomic ordering, i.e.

Feasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study.

Current treatments for narcolepsy type 1 (NT1) have little impact on psychiatric, cognitive and metabolic comorbidities. Here, we evaluated the feasibility, safety and efficacy of a prospective Exercise Training (ET) program on sleep-related symptoms and comorbidities in NT1. Sedentary adult with NT1 participated in a 6-week supervised ET program followed by a 18-week self-directed program.

Elucidating the Structure and the Impact of Synthesis Methods on the Flexibility of the Metal-Organic Framework MIL-88 A (Fe) During Water Capture.

Flexible metal-organic frameworks (MOFs) have emerged as a new generation of porous materials and are considered for various applications such as sensing, water or gas capture, and water purification. MIL-88 A (Fe) is one of the earliest and most researched flexible MOFs, but to date, there is a lack in the structural aspects that govern its dynamic behaviour. Here, we report the first crystal structure of DMF-solvated MIL-88 A and investigate the impact of real structure effects on the dynamic behaviour of MIL-88 A (Fe), particularly upon water adsorption.

The Contribution of Anesthesia Management to Childbirth-Related Posttraumatic Stress Disorder: A Case of Trauma After Denied Neuraxial Analgesia, Unmet Expectations and Remifentanil Labor Analgesia.

Childbirth-Related Posttraumatic Stress Disorder (CB-PTSD) can arise even after low-risk deliveries. This case report describes a 35-year-old woman who, despite a medically uncomplicated vaginal birth, developed severe CB-PTSD after being denied neuraxial analgesia and receiving remifentanil-PCA (remi-PCA) to manage pain. Her distress stemmed from inadequate pain relief, dissociation, and loss of control, exacerbated by unmet expectations for epidural analgesia.

Microautophagy: definition, classification, and the complexity of the underlying mechanisms.

Recently, rapid progress in the field of microautophagy (MI-autophagy) revealed the existence of multiple subtypes that differ in both intracellular membrane dynamics and molecular mechanisms. As a result, a single umbrella term "microautophagy" has become too vague, even creating some confusion among researchers both within and outside the field. We herein describe different subtypes of MI-autophagic processes and propose a systematic approach for naming them more accurately.

Teledermatological services at a Swiss university hospital - evaluation of patient benefits and economic impact .

Objectives: The aim of this study is to evaluate the potential of online consultation services in a Swiss dermatological clinic as a tool for triage, focusing on time savings, patient satisfaction, and cost-effectiveness.

Methods: Over a period of 30 months, data were generated from a publicly available store-and-forward teledermatological platform (www.derma2go.

The value of over-the-counter products/services in the management of mild-to-moderate menopausal symptoms.

For women with mild-to-moderate menopausal symptoms, lifestyle changes and over-the-counter products and services can be beneficial for symptom management, especially for those who are contraindicated or averse to using menopausal hormone therapy (MHT). Lifestyle changes, such as increased exercise and improvements in diet, enhance overall health and are suggested by some low-level evidence - largely from observational studies - to alleviate menopausal symptoms. Over-the-counter dietary and herbal supplements are a popular alternative to MHT.

Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.

Objective: Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair-bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor control center, modulates the activity of spinal locomotor centers via the reticulospinal tract. Even with severe corticospinal damage, the widely distributed reticulospinal fibers frequently cross the lesion, and lumbosacral spinal locomotor centers remain responsive.

The burden of dengue fever in travellers: a systematic literature review.

Background: Dengue is a mosquito-borne viral infection with growing global impact, including international travellers travelling to and from endemic regions. This systematic literature review aimed to assess the clinical and economic burden of dengue in travellers from non-endemic countries.

Methods: This systematic review was conducted following the PRISMA guidelines to assess the incidence, prevalence, mortality, healthcare resource use, and costs of dengue fever in travellers between non-endemic and endemic regions.

Piperacillin/Tazobactam Induced Immune-Mediated Anaemia and Thrombocytopenia.

Unlabelled: Piperacillin/tazobactam (PTZ) is known to cause cytopenia but case reports on PTZ causing combined haemolytic anaemia and thrombocytopenia are scarce. We report on a 56-year-old male who developed severe, immune-mediated thrombocytopenia and anaemia during two treatment episodes with PTZ. After the first exposure, his blood count rapidly returned to normal after discontinuation of PTZ.

Misleading Detection of Herpes Simplex Virus Type 1 In A Patient with Paraneoplastic Encephalitis.

Unlabelled: Encephalitis is a potentially life-threatening condition with infectious or autoimmune aetiologies. Autoimmune encephalitis includes paraneoplastic variants associated with specific onconeural antibodies such as anti-Hu, frequently linked to malignancies. Herpes simplex virus type 1 (HSV-1) is the leading infectious cause in adults.

iPSC-hepatocyte organoids as a novel platform to predict AAV gene therapy efficacy.

Adeno-associated virus (AAV) vectors are widely used in gene therapy, particularly for liver-targeted treatments. However, predicting human-specific outcomes, such as transduction efficiency and hepatotoxicity, remains challenging. Reliable models are urgently needed to bridge the gap between preclinical studies and clinical applications.

Recent Advances in Metal-Organic Frameworks for Electromagnetic Wave Absorption.

With the rapid advancement of communication technologies, issues of electromagnetic pollution and electromagnetic compatibility have become increasingly severe, heightening the demand for high-performance electromagnetic wave absorption materials. Metal-organic frameworks (MOFs) have flourished in this field owing to their chemical tunability, high porosity, tailored topological structures, and functionality. MOF-derived composites exhibit diverse loss mechanisms and heterogeneous structures, achieving lightweight, broadband, and highly efficient absorption.

Citizens and the public perception of lobbying: do regulation and trust in political institutions make a difference?

In political studies, lobbying is portrayed as a vital process of political participation, contributing information, policy capacities, and political capital to policymaking, but also as a potential source of representation biases, undue influence, and policy capture. Given such Janus-faced nature of lobbying within democracy, the primary aim of this article is to investigate which perception prevails among citizens empirically. By analysing the primary data of two surveys of 4000 Canadian and 1600 Swiss citizens, it investigates the public perception of lobbying across countries with contrasting institutional and regulatory frameworks and different levels of trust in political institutions.

Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.

Objective: Vitamin C has been linked to alterations in platelet count and aggregation behavior. Given recent findings suggesting an association between vitamin C and adverse outcomes in patients with septic shock, we aimed to investigate whether vitamin C influences mortality in septic patients through its impact on platelets.

Design: Post hoc analysis of the Lessening Organ Dysfunction With Vitamin C (LOVIT) randomized trial (clinicaltrials.

Do Open Fracture Classification Systems Predict Functional Outcomes in a Low-Income Country?: A Prospective Study of 287 People with Open Tibia Fractures in Malawi.

Background: Open fractures are common and severe injuries that are associated with poor functional outcomes and quality of life, and high societal costs. Several classifications systems have been developed to characterize these injuries, predict prognosis and plan treatment. We aimed to assess the agreement between open fracture classification and patient-reported function, fracture-related infection, and amputation.

Radiomics features from the peritumoral region can be associated with the epilepsy status of glioblastoma patients.

Purpose: Identifying radiomics features that help predict whether glioblastoma patients are prone to developing epilepsy may contribute to an improvement of preventive treatment and a better understanding of the underlying pathophysiology.

Materials And Methods: In this retrospective study, 3-T MRI data of 451 pretreatment glioblastoma patients (mean age: 61.2 ± 11.

Investigating metal distribution patterns in pristine and ocean-weathered plastics using LA-ICP-TOFMS.

Plastic pollution in marine environments poses ecological risks, in part because plastic debris can release hazardous substances, such as metal-based additives. While microplastics have received considerable attention as vectors of contaminants, less is known about larger macroplastics and their role in the spatial and temporal redistribution of substances. In this study, pristine, store-bought plastic items and macroplastics recovered from the North Pacific Subtropical Gyre (NPSG) were analysed using Fourier-Transform Infrared Spectroscopy (FTIR) to identify polymer types, and bulk acid digestion followed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for total metal quantification.

Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit.

Herein we present the rapid development of LH168, a potent and highly selective chemical probe for WDR5, streamlined by utilizing a DEL-ML (DNA encoded library-machine learning) hit as the chemical starting point. LH168 was comprehensively characterized in bioassays and demonstrated potent target engagement at the WIN-site pocket of WDR5, with an EC of approximately 10 nM, a long residence time, and exceptional proteome-wide selectivity for WDR5. In addition, we present the X-ray co-crystal structure and provide insights into the structure-activity relationships (SAR).

The Case for Limiting "Sequences of Concern" to Those with Demonstrated Pathogenic Function.

Screening synthetic nucleic acid orders for sequences of concern is a necessary part of a healthy biosecurity regime, but it exacts costs for nucleic acid providers. Taxonomy is and will remain a critical part of the decision-making process for screening, especially for viral sequences. But, moving forward, the function of a sequence will also be determinative of its level of concern, or lack thereof.