Population-adjusted cut-off: A new approach for enhancing the diagnostic efficacy of hematological discrimination formulae for screening β-Thalassemia trait.

Screening for β-thalassemia trait (βTT) is crucial for preventing β-thalassemia major in offspring. Although hematological discrimination formulae (HDF), developed using complete blood count parameters, are cost-effective tools for screening βTT, their performance varies across different populations. This study evaluated the performance of 32 HDF for screening βTT in the Sri Lankan population.