Sustainable synthesis of Schiff base derivatives an ionic liquid and a microwave-assisted approach: structural, biological, and computational evaluation.

A sustainable and efficient microwave-assisted strategy was developed for the synthesis of novel 4-amino-pyrrolo [2,3-]pyrimidine-based Schiff base derivatives (APR1a-d), utilizing the ionic liquid 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([HMIM][TFSI]) as both catalyst and solvent. This green protocol afforded high yields (82-94%) under mild conditions with excellent reusability of the ionic liquid. Structural confirmation was achieved FT-IR, H and C NMR, and mass spectrometry.