Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway.

Background: Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a very high disability and mortality rate, which brings a huge economic burden to society. It is reported that inhibition of forkhead box O3 (FOXO3) can alleviate brain edema and neuroinflammation after SAH. However, the role and mechanism of FOXO3 in regulating SAH progression need to be further studied.