Yohimbine as a multifunctional therapeutic agent: inhibition of lysozyme aggregation, glycation and antioxidant properties.

Protein misfolding and glycation are central to the pathogenesis of several chronic diseases, including neurodegenerative disorders and diabetes. Lysozyme (Lyz), a model protein, serves as an excellent system to study these pathological processes due to its propensity to form amyloid fibrils and undergo glycation. This study investigates the multifunctional therapeutic potential of yohimbine (Yoh) as an inhibitor of Lyz aggregation and glycation and its role as an antioxidant.