The relationship between pain and depression and anxiety in people with inflammatory arthritis: A systematic review.

Objective: This PROSPERO-registered (CRD42023411823) systematic review synthesised literature on the associations between pain and depression/anxiety in inflammatory arthritis, including the direction of effect, relationship mediators, and treatment impacts.

Methods: Protocolised-database searches were conducted to May-2023 and studies assessing the associations between pain and depression/anxiety and/or impacts of depression/anxiety treatment on pain in people with rheumatoid arthritis/spondyloarthritis identified. Studies with mixed-populations, non-translatable non-English studies, case-reports/series/reviews/editorials, and abstracts/letters with insufficient-data were excluded.

Examining the Effect of SNAP-Multibehaviours on Multimorbidity Risk: A Cross-Sectional Study in Three General Practices' Electronic Health Records.

Background: The growing challenge of multimorbidity for healthcare systems worldwide demands a dual prevention framework, targeting both primary and secondary prevention. Multimorbidity-multibehaviours can provide such a theoretical and clinical framework to explore new aetiological evidence for multimorbidity risk. While the role of single health risk behaviours, such as smoking, nutrition, alcohol, and physical activity (SNAP), in chronic disease prevention is well-documented, their synergistic effect on multimorbidity has received relatively little attention.

Long COVID Optimal Health Programme to Enhance Mental and Physical Health: A Feasibility Randomised Controlled Trial.

Introduction: Long COVID (LC) is characterised by fatigue, muscle weakness and impaired concentration among other symptoms. No standardised diagnostic or treatment pathway is yet available, though a holistic, person-centred approach to symptom management is recommended. The LC Optimal Health Programme (LC-OHP) is a psychoeducational programme designed to support the mental and physical health of people with LC.

The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine.

Objectives: Only 12% of people recommended fracture prevention medicines remain on treatment 1 year post fracture. The improving uptake of Fracture Prevention treatments (iFraP) intervention aims to improve shared decision-making (SDM) about, and uptake of, osteoporosis medicines in Fracture Liaison Services (FLS). This paper details development and feasibility.

Osteoporosis care in primary care settings: a national UK e-survey.

Unlabelled: An electronic survey of 341 UK primary care staff identified barriers to evidence-based osteoporosis care including low confidence in clinical skills, the complex nature of decision-making, insufficient incentivisation and lack of systematic case finding. Opportunities to enhance osteoporosis care may include enhanced education and wider utilisation of the extended workforce.

Purpose: To investigate the beliefs, confidence and practices of general practice staff in the care of people with, or at increased risk of, osteoporotic fractures and the association between professional role and beliefs and confidence about osteoporosis care.

Remote Digital Health Interventions to Support the Physical, Functional, or Psychological Rehabilitation of Adult Patients With Major Traumatic Injuries: Protocol for a Systematic Review of Randomized Controlled Trials.

Background: The use of digital health (DH) interventions has increased over the past 2 decades, providing patients with alternative remote pathways for receiving health care services. Patients with major trauma frequently require long-term access to health care services to support their mental and physical health and their overall quality of life. DH interventions can help patients stay connected to rehabilitation services, thereby enhancing their health condition and helping them regain their independence, which will enable them to return to the workplace or regain a role in society.

Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross-Sectional Survey.

Introduction: Polymyalgia rheumatica (PMR) international management guidelines advocate patient education and individualised exercises but lack evidence and physiotherapy practice for PMR is unknown. PMR is typically treated with glucocorticoids, but side effects are frequent and concerning to patients. This study investigated UK physiotherapy practice in PMR.

Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK.

Background: About 30% of patients with depression treated with antidepressant medication do not respond sufficiently to the first agents used. Pramipexole might usefully augment antidepressant medication in such cases of treatment-resistant depression, but data on its effects and tolerability are scarce. We aimed to assess the efficacy and tolerability of pramipexole augmentation of ongoing antidepressant treatment, over 48 weeks, in patients with treatment-resistant depression.

Systematic Evaluation of How Indicators of Inequity and Disadvantage Are Measured and Reported in Population Health Evidence Syntheses.

We present a systematic evaluation of population health reviews from the Cochrane Database (January 2013-February 2023) to evaluate how indicators of inequity or disadvantage are considered and reported in population health evidence syntheses. Descriptive analyses explored a representation of reviews across health-determinant categories (primary and secondary categories), summarised equity-focused reviews, and examined proportions and types of reviews that planned/completed a subgroup analysis using ≥1 indicators from the PROGRESS-Plus framework. Of 363 reviews included, a minority focused on interventions targeting wider determinants of health (n = 83, 22.

Local variation in musculoskeletal pain consultation rates in primary care: findings from an ecologic study in Staffordshire.

Variation between general practices in the rate of consultations for musculoskeletal pain conditions may signal important differences in access to primary care, perceived usefulness, or available alternative sources of care; however, it might also just reflect differences in underlying 'need' between practices' registered populations. In a study of 30 general practices in Staffordshire, we calculated the proportion of adults consulting for a musculoskeletal pain condition, then examined this in relation to selected practice and population characteristics, including the estimated prevalence of self-reported musculoskeletal problems and chronic pain in each practices' registered population. Between September 2021 and July 2022, 18,388 adults were consulted for a musculoskeletal pain condition.

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Objectives: To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation.

Design: A descriptive cross-sectional study.

Setting: 10 general practices in the West Midlands, England.

Age equality in mental health: Déjà vu all over again.

Aims: Ageism is one of the last socially accepted prejudices. This paper aims to highlight key areas of age discrimination and inequality in mental health services.

Discussion: It will discuss examples, drawn mainly from the UK, in terms of mental health inequalities to illustrate age inequality.

Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Background: Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs) of exercises and orthoses for PHP.

Objectives: To determine the clinical and cost-effectiveness of individualised exercises and/or prefabricated foot orthoses plus self-management advice (SMA) compared to SMA alone in adults with PHP.

Physiotherapy Capabilities in the Health Care of Adult Patients at Increased Risk of Osteoporotic Fractures: A Scoping Review Protocol.

Objectives: This scoping review will explore and map the extent and type of literature related to physiotherapy capabilities in the health care of adult patients at increased risk of osteoporotic fractures and identify gaps in the literature.

Background: With an ageing population, osteoporosis and fractures and their associated costs are increasing. Unfortunately, many people with, or at increased risk of, osteoporotic fractures remain undiagnosed and untreated.

HIV seroconversions and genotypic viral resistance profiles in the PrEP impact trial.

Objectives: Here we describe HIV seroconversion events in participants of the PrEP Impact trial.

Methods: Of 24 268 participants, we reviewed data for the 54 who were diagnosed with HIV during the trial; 11 at baseline.

Results: Incidence was low for those diagnosed pre-pandemic at 0.

The impact of intensive management on pain intensity in patients with rheumatoid arthritis and psoriatic arthritis: secondary analysis of three clinical trials.

Background: Understanding the impact of intensive treatment on pain in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) is crucial to informing the application of evidence-based arthritis pain care. The impact of intensive treatment on inflammatory arthritis pain has received relatively limited attention. We addressed this through a detailed secondary analysis of three trials evaluating varying intensities of disease-modifying anti-rheumatic drug treatment.

Getting to what matters for people with osteoporosis in clinical consultations with and without conversation aids: A videographic analysis.

Objective: To evaluate if, and how, clinicians elicit and address health and medicine beliefs in osteoporosis consultations, and to evaluate the impact of a conversation aid (CA) on clinician behaviour.

Methods: Secondary analysis of 107 video-recorded consultations from two trials evaluating CAs, using a bespoke coding tool to record the presence or absence of clinician shared decision-making (SDM) behaviours. In addition to descriptive statistics, Fisher's exact test examined differences between consultations with and without CAs.

Healthcare use and its variation in people with fibromyalgia: a systematic review protocol.

Aim: A crucial step towards improving the care of people with fibromyalgia is understanding current practice. Our systematic review aims to address this by synthesising the global evidence around healthcare use in people with fibromyalgia, including its variation across groups of people, geographical locations, and over time.

Background: Fibromyalgia is a chronic condition characterized by widespread pain alongside a broad range of non-pain symptoms.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear information, and timely, tailored consultations for their pain. This trial will evaluate the introduction of a personalised guided consultation to help physiotherapists manage care for individuals with shoulder pain.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long-Term for Persistent Pain in Primary Care.

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well-reported. We outline how stakeholders contributed to co-designing a Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by Pharmacists working in primary care Teams (the PROMPPT intervention-a review and pharmacist training package).

Methods: We brought key stakeholders together to co-design the PROMPPT intervention using a person-based approach, alongside evidence from best practice guidance.

Sex-Specific Multimorbidity-Multibehaviour Patterns in Primary Care Populations.

Background: A conceptual shift in healthcare emphasises multimorbidity and multibehaviours as interconnected phenomena, highlighting dose-response associations and sex-specific differences. Data-driven approaches have been suggested for overcoming methodological challenges, of multimorbidity research. By using exploratory factor analysis, this study aimed to identify sex specific lifestyle associative multimorbidity patterns, providing valuable evidence to primary care providers and informing future multimorbidity guidelines.