4 results match your criteria: "Israel. Electronic address: sstern@univ.haifa.ac.il.[Affiliation]"
Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview.
Schizophr Res
November 2024
Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3498838, Israel. Electronic address:
Article Synopsis
- Schizophrenia (SCZ) is a hereditary and complex neuropsychiatric disorder that impairs patients' lives and reduces their life expectancy and quality of life.
- Research has identified over 100 genomic loci related to SCZ, but no direct causative genes have been discovered, complicating efforts to model the disease in animals.
- Induced Pluripotent Stem Cells (iPSCs) have emerged as a valuable tool for studying SCZ, enabling researchers to explore neural traits through patient-derived neuronal cultures and brain organoids, enhancing our understanding of the disease's genetics and underlying mechanisms.
Generation and characterization of iPSC lines (UOHi003-A, UOHi002-A) from a patient with SHANK3 mutation and her healthy mother.
Stem Cell Res
October 2022
Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel. Electronic address:
Phelan-McDermid syndrome (PMS) is a rare genetic condition that causes global developmental disability, delayed or absent speech, and an autism spectrum disorder. The loss of function of one copy of SHANK3, which codes for a scaffolding protein found in the postsynaptic density of synapses, has been identified as the main cause of PMS. We report the generation and characterization of two induced pluripotent stem cell (iPSC) lines derived from one patient with a SHANK3 mutation and the patient's mother as a control.
View Article and Find Full Text PDFA Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients.
Biol Psychiatry
July 2020
Laboratory of Genetics, Gage Lab, Salk Institute for Biological Studies, La Jolla, California. Electronic address:
Background: We recently reported a hyperexcitability phenotype displayed in dentate gyrus granule neurons derived from patients with bipolar disorder (BD) as well as a hyperexcitability that appeared only in CA3 pyramidal hippocampal neurons that were derived from patients with BD who responded to lithium treatment (lithium responders) and not in CA3 pyramidal hippocampal neurons that were derived from patients with BD who did not respond to lithium (nonresponders).
Methods: Here we used our measurements of currents in neurons derived from 4 control subjects, 3 patients with BD who were lithium responders, and 3 patients with BD who were nonresponders. We changed the conductances of simulated dentate gyrus and CA3 hippocampal neurons according to our measurements to derive a numerical simulation for BD neurons.
Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder.
Biol Psychiatry
July 2020
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California. Electronic address:
Background: Approximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of induced pluripotent stem cell methodology enabled better modeling of this disorder.
Methods: Having previously studied the phenotype of dentate gyrus granule neurons, we turned our attention to studying the phenotype of CA3 hippocampal pyramidal neurons of 6 patients with BD compared with 4 control individuals.