514 results match your criteria: "Institute of Endocrinology and Diabetes[Affiliation]"
Classical and Nonclassical Manifestations of Primary Hyperparathyroidism.
J Bone Miner Res
November 2022
Department of Clinical and Experimental Medicine, Endocrine Unit 2, University Hospital of Pisa Chairman European Group on Graves' Orbitopathy Via Paradisa 2, University of Pisa Head, Pisa, Italy.
Article Synopsis
- This review examines the current understanding of primary hyperparathyroidism (PHPT), highlighting both classical and nonclassical symptoms, and is based on extensive literature research.
- * The shift towards asymptomatic presentations of PHPT presents new challenges, particularly regarding the unclear progression of such cases and their potential links to cardiovascular and neuropsychological issues.
- * The review calls for a clearer definition of asymptomatic PHPT, suggesting the need for more refined diagnostic criteria and further research into its various manifestations and impact on quality of life.
Timing of submissions to The Journal of Paediatrics and Child Health: Associations with the COVID-19 pandemic and editorial decisions.
J Paediatr Child Health
January 2023
School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia.
Aim: To determine if the timing of manuscript submissions to The Journal of Paediatrics and Child Health (JPCH) changed following the onset of the COVID-19 pandemic and to determine if the timing of manuscript submissions influenced editorial decisions.
Methods: A retrospective observational study of submissions to JPCH from 1 January 2015 to 1 August 2022 was performed. Regression models were used to explore the change over time.
Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats.
Horm Metab Res
November 2022
Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.
Nesfatin-1, the cleavage product of nucleobindin-2, is an anorexigenic peptide and major regulator of energy homeostasis. Beyond reducing food intake and increasing energy expenditure, it is also involved in regulating the stress response. Interaction of nucleobindin-2/nesfatin-1 and glucose homeostasis has been observed and recent findings suggest a link between the action of the antidiabetic drug metformin and the nesfatinergic system.
View Article and Find Full Text PDFThe COVID-19 Pandemic Affects Seasonality, With Increasing Cases of New-Onset Type 1 Diabetes in Children, From the Worldwide SWEET Registry.
Diabetes Care
November 2022
Children's Hospital Auf Der Bult, Hannover Medical School, Hannover, Germany.
Objective: To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally.
Research Design And Methods: We analyzed data on 17,280 cases of T1D diagnosed during 2018-2021 from 92 worldwide centers participating in the SWEET registry using hierarchic linear regression models.
Results: The average number of new-onset T1D cases per center adjusted for the total number of patients treated at the center per year and stratified by age-groups increased from 11.
Mindful and Intuitive Eating Imagery on Instagram: A Content Analysis.
Nutrients
September 2022
Children's Hospital Westmead Clinical School, The University of Sydney, Westmead 2145, Australia.
Non-dieting approaches, including mindful/intuitive eating, to health improvement are of increasing interest, yet little is known about young adults' social media exposure to them. Therefore, this study aimed to describe the imagery related to mindful/intuitive eating which is visible to young adult Instagram users. Images categorized under the hashtags 'mindfuleating' and 'intuitiveeating' were searched in September 2021 using the 'top posts' view.
View Article and Find Full Text PDFContent Analysis of #Postpartumbody Images Posted to Instagram.
Healthcare (Basel)
September 2022
Health and Social Care Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Understanding the imagery on social media targeting postpartum women is an important step in determining the utility of Instagram as a potential avenue for targeting public health messages to this group. This study (1) describes the content of images on Instagram tagged with #postpartumbody and; (2) compares images from ‘Top’ posts (‘trending’ or ‘popular’) with ‘Recent’ posts. 600 images tagged with #postpartumbody (300 ‘Top’ and 300 ‘Recent’) were systematically captured from Instagram and coded using a predefined framework.
View Article and Find Full Text PDFAntenatal diet quality and perinatal depression: the Microbiome Understanding in Maternity Study (MUMS) cohort.
J Hum Nutr Diet
June 2023
School of Women and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Article Synopsis
- The study explored the link between diet quality during pregnancy and the risk of postpartum depression (PPD), finding previous research had inconsistent results.
- It involved 73 women tracked from early pregnancy to one year postpartum, assessing diet quality and depression using established scoring systems.
- Results showed strong correlations between depression scores during pregnancy and those at 6 weeks postpartum, but diet quality did not significantly relate to PPD, suggesting the need for more comprehensive studies on the topic.
Early Life Determinants of Vascular Structure in Fetuses, Infants, Children, and Adolescents: A Systematic Review and Meta-Analysis.
J Pediatr
January 2023
University of Sydney Children's Hospital Westmead Clinical School, Sydney, Australia; School of Women's and Children's Health, The University of New South Wales, Sydney, Australia; Institute of Endocrinology and Diabetes, Children's Hospital at Westmead, Sydney, Australia. Electronic address: megan.
Objective: To investigate the association between early life exposures during the first 1000 days (conception to age 24 months) and aortic intima-media thickness (aIMT), an early indicator of cardiovascular disease (CVD) risk, in youths.
Study Design: The MEDLINE, Embase, Scopus, CINAHL, and Allied and Complementary Medicine databases were searched from inception to July 2021. Eligibility criteria included observational controlled studies in youths aged <20 years with risk factors/exposures during the first 1000 days and aIMT measurements (unadjusted mean ± SD).
Epidemiology of Type 1 Diabetes.
Curr Cardiol Rep
October 2022
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.
Article Synopsis
- Type 1 diabetes (T1D) is increasingly being recognized as a disease that affects people of all ages, not just children, with studies showing higher diagnoses in adults.* -
- The incidence of T1D varies geographically, being highest in Northern Europe and lowest in Asia, and adult-onset T1D tends to have a less severe initial presentation compared to childhood onset.* -
- Emerging interventions aim to delay the onset of T1D, and complications associated with the disease, such as macro and microvascular issues, pose significant health risks for adults diagnosed with T1D.*
Optimal Frequency of Retinopathy Screening in Adolescents With Type 1 Diabetes: Markov Modeling Approach Based on 30 Years of Data.
Diabetes Care
October 2022
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Article Synopsis
- Current guidelines suggest biennial screening for diabetic retinopathy (DR) starting at age 11, but new evidence indicates that less frequent screening might be sufficient for youth with type 1 diabetes.* -
- A study involving over 2,000 young individuals with type 1 diabetes found that the incidence of moderate or worse DR was relatively low, and transitions to more severe stages were influenced by factors like HbA1c levels and diabetes duration.* -
- The findings support the idea of reducing the frequency of DR screenings for young patients without existing DR, as the progression to severe stages tends to be slow, with higher HbA1c levels significantly increasing the risk of advancement.*
Exacerbation of disordered eating behaviors in adolescents with type 1 diabetes during the COVID-19 pandemic: reply.
Acta Diabetol
October 2022
The Institute of Endocrinology and Diabetes, Schneider Children's Medical Center, 4920235, Petah Tikva, Israel.
Parent Guide to Child Healthy Weight Programs.
JAMA Pediatr
September 2022
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.
In the past 4 decades, the number of children in the US with obesity has more than tripled.
View Article and Find Full Text PDFDietary Behavior and Compliance to Bulgarian National Nutrition Guidelines in Patients With Type 1 Diabetes With Longstanding Disease.
Front Nutr
July 2022
Department of Paediatrics, Medical University of Varna, Varna, Bulgaria.
Introduction: Nutrition education attempts to maintain and enhance good eating habits to achieve optimal metabolic control in people with type 1 diabetes (T1D). Recommendations for patients with T1D are comparable to those of the general population.
This Study Aimed: To investigate dietary habits and adherence to nutritional recommendations of patients with T1D as compared with age, gender, and BMI matched people in Bulgaria.
Higher frequency of cardiovascular autonomic neuropathy in youth with type 2 compared to type 1 diabetes: Role of cardiometabolic risk factors.
Pediatr Diabetes
November 2022
The University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.
Objective: Cardiovascular autonomic neuropathy (CAN) is an overlooked but common and serious diabetes complication. We examined CAN in youth with diabetes and associations with cardiovascular risk factors.
Research Design And Methods: This was a prospective cohort of youth aged <20 years with type 2 or type 1 diabetes (n = 66/1153, median age 15.
Integrated guidance to enhance the care of children and adolescents with familial hypercholesterolaemia: Practical advice for the community clinician.
J Paediatr Child Health
August 2022
School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Article Synopsis
- * In Australia and New Zealand, an estimated 22,000 children and teens have FH, yet many go unnoticed until later in life or after heart problems arise.
- * The paper aims to boost awareness and provide practical guidelines for diagnosing and managing FH in young people, including the use of treatments and genetic testing, while emphasizing the need for targeted detection and tailored care models to improve health outcomes.
Identifying eating disorders in adolescents and adults with overweight or obesity: A systematic review of screening questionnaires.
Int J Eat Disord
September 2022
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Objective: This review aimed to examine the validity of self-report screening questionnaires for identifying eating disorder (ED) risk in adults and adolescents with overweight/obesity.
Method: Five databases were searched from inception to September 2020 for studies assessing validation of self-report ED screening questionnaires against diagnostic interviews in adolescents and adults with overweight/obesity. The review was registered with PROSPERO (https://www.
Snapshot of CGM Metrics in Adolescents and Adults Achieving Target HbA1c Versus Those Not Meeting Target HbA1c.
Diabetes Technol Ther
September 2022
Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Australia.
Hybrid closed-loop therapy with a first-generation system increases confidence and independence in diabetes management in youth with type 1 diabetes.
Diabet Med
September 2022
Children's Diabetes Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
Aim: Hybrid closed-loop (HCL) therapy improves glycaemic control in adolescents with type 1 diabetes; however, little is known about their lived experience using these systems. The aim of this study was to explore the lived experiences of youth with type 1 diabetes using HCL therapy, and their parents, to provide insight into their lived experiences.
Methods: Adolescents and young adults aged 12-25 years, who used Medtronic MiniMed™ 670G HCL system during a 6-month randomised clinical trial, and their parents, were invited to participate in a semi-structured interview at the end of the study.
Glycemic status and general characteristics among individuals with undiagnosed diabetes; findings from second National Diabetes Survey of Pakistan 2016-2017 (NDSP 08).
Diabetes Metab Syndr
June 2022
Biochemistry Department, Baqai Medical University, Karachi, Pakistan. Electronic address:
Background And Aim: To observe the glycemic status among individuals with undiagnosed diabetes in urban and rural areas of all four provinces of Pakistan.
Methods: The findings of this study are obtained from the second National Diabetes Survey of Pakistan (NDSP) 2016-2017, a nationwide epidemiological survey. Out of 12,486 individuals approached, 10,834 participants agreed to be included in the second NDSP.
Structural Characterization and In-Vitro Antioxidant and Immunomodulatory Activities of Polysaccharide Fractions Isolated from L.
Molecules
June 2022
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Arimisia annua L. is an important anticancer herb used in traditional Chinese medicine. The molecular basis underpinning the anticancer activity is complex and not fully understood, but the herbal polysaccharides, broadly recognised as having immunomodulatory, antioxidant and anticancer activities, are potential key active agents.
View Article and Find Full Text PDFChildhood type 1 diabetes is associated with abnormal bone development.
Pediatr Diabetes
September 2022
Children's Hospital Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Article Synopsis
- Adolescents with type 1 diabetes (T1D) show reduced bone mineral density (BMD) in specific areas like the femoral neck and arm, while total lumbar spine BMD remains normal.
- A significant 50% fracture prevalence was found among the study participants, indicating a potential risk for bone health issues.
- Correlations were observed between bone density and factors like BMI and age at T1D diagnosis, but other diabetes-related metrics, including HbA1c and microvascular complications, did not significantly impact bone parameters.
Thirty-Year Time Trends in Diabetic Retinopathy and Macular Edema in Youth With Type 1 Diabetes.
Diabetes Care
October 2022
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, Australia.
Objective: To examine trends in diabetic retinopathy (DR) and diabetic macular edema (DME) in adolescents with type 1 diabetes between 1990 and 2019.
Research Design And Methods: We analyzed 5,487 complication assessments for 2,404 adolescents (52.7% female, aged 12-20 years, diabetes duration >5 years), stratified by three decades (1990-1999, 2000-2009, 2010-2019).
Optic pathway glioma and endocrine disorders in patients with and without NF1.
Pediatr Res
January 2023
Institute of Endocrinology and Diabetes, National Center of Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Background: Optic pathway gliomas (OPGs) are classified by anatomic location and the association with neurofibromatosis type 1 (NF1). Children with OPGs face sequelae related to tumor location and treatment modalities. We assessed the prevalence of endocrine dysfunction in children with OPGs and compared outcomes between those with and without NF1.
View Article and Find Full Text PDFYouth-onset type 2 diabetes in Israel: A national cohort.
Pediatr Diabetes
September 2022
Pediatric Diabetes Clinic, Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel.
Background: Prevalence of youth-onset type 2 diabetes (T2D) has increased worldwide, paralleling the rise in pediatric obesity. Occurrence and clinical manifestations vary regionally and demographically.
Objectives: We assessed the incidence, and clinical and demographic manifestations of youth-onset T2D in Israel.
Genetic Etiology of Neonatal Diabetes Mellitus in Vietnamese Infants and Characteristics of Those With Gene Mutations.
Front Endocrinol (Lausanne)
May 2022
The Center of Endocrinology, Metabolism, Genetics, and Molecular Therapy, Vietnam National Children's Hospital, Hanoi, Vietnam.
Article Synopsis
- * A study involving 70 infants diagnosed with NDM at the Vietnam National Children's Hospital found that 78.5% had known mutations, with many experiencing diabetic complications but showing normal development after 5.5 years of insulin treatment.
- * The research highlights that certain mutations are a common cause of permanent NDM and suggests that genetic screening for these mutations should be part of the diagnosis process for diabetic children in their first year of life.