Upcycling PET waste into Zn-MOF integrated chitosan-PEG semi-IPN foams for rapid congo red removal with high regeneration efficiency: DFT insights into adsorption mechanism.

Plastic pollution, especially from polyethylene terephthalate (PET) waste, presents a significant environmental threat. In this study, a sustainable approach is demonstrated by upcycling PET waste into a zinc-based metal-organic framework (Zn-TPA MOF) and integrating it into a chitosan (CS)/polyethylene glycol (PEG) semi-interpenetrating polymer network (semi-IPN) to fabricate a porous composite foam via solution casting and freeze-drying. The resulting Zn-TPA@CS/PEG foam exhibits a highly porous architecture, mechanical robustness, and abundant active sites, enabling efficient dye adsorption.

Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer.

Development of advanced therapeutic modalities for the treatment of cancer are become a thirst area in the field of biomedical science now a day. Current therapeutic approaches to treat this fatal disease always refer to partial curability with unavoidable obstacles. Here, we have developed stearic-g-polyethyleneimine acid amphiphilic nanomicelle functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (doxorubicin, DOX) delivery and concurrent bio-imaging for triple negative breast cancer (TNBC).

Natural polysaccharide derived carbon dot based in situ facile green synthesis of silver nanoparticles: Synergistic effect on breast cancer.

Over the decades, several nanoparticles have been developed for biomedical applications, still facile green synthesis derived nanoparticles showed tremendous attraction due to avoid of toxic solvent, ease of synthesis and low cost. Here, facile one pot in situ green synthesis is reported to develop silver nanoparticles with the aid of natural polysaccharide presented in sweet lemon peel waste derived carbon dot (CD) acted as a reducing and stabilizing agent at room temperature. The synthesis of CD and CD based silver nanoparticles (CD@AgNPs) was characterized by FTIR, UV-vis spectroscopy, fluorescence spectrophotometer, XRD and TEM.

Low molecular weight polyethyleneimine conjugated guar gum for targeted gene delivery to triple negative breast cancer.

The study emphasized on the development of an efficient, receptor-targeted non-viral gene delivery vehicle for gene therapy of triple negative breast cancer (TNBC). Here, naturally abundant guar gum based non-viral carrier was developed through conjugating by low molecular weight polyethylenimine (LPEI) (GNP) using napthalic anhydride coupling agent and characterized them by FT-IR, H NMR, XRD and UV spectrophotometer. The carrier was found to be cytocompatible as revealed by MTT assay against MDA-MB-231 and HeLa cell lines and excellent blood compatibility till the concentration of 200 μg/ml.