Design and development of Ondansetron-loaded polysaccharide-based buoyant formulation for improved gastric retention and drug release, using both natural and semi-synthetic polymers.

Extended gastric residence of drugs can enhance the therapeutic effect, increase bioavailability, improve efficacy, and reduce the number of required doses by prolonging the retention of the drug delivery system. A new floating drug delivery for Ondansetron was designed and evaluated. Pre-formulation studies included the assessment of powder flow properties and drug-excipient compatibility.