1 results match your criteria: "Hungary. tamasi.viola@med.semmelweis-univ.hu.[Affiliation]"
High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes.
Nutr Metab (Lond)
March 2023
Department of Molecular Biology, Semmelweis University, Tűzoltó U. 37-47, Budapest, 1094, Hungary.
Article Synopsis
- High fat diets (HFD) can lead to serious conditions like dyslipidemia, atherosclerosis, and diabetes, but the effects on liver lipid levels haven't been thoroughly studied before.
- This study aimed to investigate how HFD affects triglycerides, diglycerides, ceramides, and key lipid-related genes in the liver, while also exploring the role of the protein PCSK9 using specially bred mice.
- The results showed HFD decreased PCSK9 levels while increasing other lipid-related proteins and hepatic triglycerides, suggesting that HFD-induced changes in liver lipid accumulation mimic those seen in PCSK9 deficiency.