2 results match your criteria: "France. Electronic address: wilfried.le_goff@sorbonne-universite.fr.[Affiliation]"
Biomimetic high-density lipoprotein nanoparticles for the delivery of nucleic acid-based therapeutics.
Biotechnol Adv
October 2025
Chemical and Biological Integrative Research Center, Biomedical Research Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, 02792 Seoul, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang
The field of delivering nucleic acids (NAs) via high-density lipoprotein-mimicking nanoparticles (HDL NPs) has shown promising advancements over the past two decades. HDL NPs are designed to efficiently bind NAs, safeguard them from degradation, and help navigate through various biological barriers to deliver them into the target cell's cytosol. Some HDL NPs allow direct cytosolic delivery of NAs by a selective mechanism with the involvement of HDL's natural receptor scavenger receptor class B type I (SR-B1).
View Article and Find Full Text PDFImpaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus.
EBioMedicine
October 2023
Sorbonne Université, INSERM, Foundation for Innovation in Cardiometabolism and Nutrition (IHU ICAN), UMR_S1166, F-75013, Paris, France. Electronic address:
Background: Patients with systemic lupus erythematosus (SLE) exhibit a high risk for cardiovascular diseases (CVD) which is not fully explained by the classical Framingham risk factors. SLE is characterized by major metabolic alterations which can contribute to the elevated prevalence of CVD.
Methods: A comprehensive analysis of the circulating metabolome and lipidome was conducted in a large cohort of 211 women with SLE who underwent a multi-detector computed tomography scan for quantification of coronary artery calcium (CAC), a robust predictor of coronary heart disease (CHD).