3 results match your criteria: "Doheny Image Reading and Research Lab (DIRRL) - Doheny Eye Institute[Affiliation]"

Real-World Outcomes in Eyes With Neovascular AMD Switched From Brolucizumab to Faricimab: A TRUCKEE Study Analysis.

Am J Ophthalmol

August 2025

Doheny Image Reading & Research Lab (DIRRL), Doheny Eye Institute (C.S., G.C., M.A., S.S.), Pasadena, California, USA; Department of Ophthalmology (C.S., G.C., M.A., S.S.), University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA. Electronic address: SSadda@

Objective: To investigate anatomical and functional outcomes in a subset of eyes with neovascular age-related macular degeneration (nAMD) switched from brolucizumab to faricimab in the real-world TRUCKEE study.

Design: Retrospective, multicentric clinical cohort study.

Subjects And Participants: 134 eyes of 108 patients were switched from brolucizumab to faricimab.

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Purpose: To generate and validate a spectral domain optical coherence tomography angiography (SD-OCTA) device-specific algorithm to compensate for signal attenuation in choriocapillaris (CC) en face OCTA slabs.

Methods: Healthy subjects were imaged on SD-OCTA with a 6 × 6 mm pattern at the Doheny-UCLA Eye Centers. The CC slabs were segmented at the level of the Bruch's membrane using a 16-μm thick slab with the inner boundary located 4 μm below the Bruch's membrane.

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Article Synopsis
  • Estimating health loss trends in Peru from 1990 to 2019 is crucial for improving healthcare resource allocation and system performance, using data from the Global Burden of Disease study.
  • The Peruvian population rose to 33.9 million by 2019, with life expectancy at birth increasing from 69.2 to 80.3 years, largely due to a decrease in under-5 mortality and infectious diseases, while disability-adjusted life-years (DALYs) showed a decline in overall health burden.
  • There was a notable shift towards non-communicable diseases as the leading cause of health loss, with major contributors to DALYs in 2019 including neonatal disorders, lower respiratory infections, and lifestyle
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