3 results match your criteria: "Collaboration Research Center for Precision Oncology based Omics (PKR PrOmics)[Affiliation]"
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes.
PLoS One
May 2025
Department of Pharmaceutical Sciences, Faculty of Medicine, Universitas Negeri Semarang, Semarang, Indonesia.
Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Luminal A and B BC, characterized by estrogen receptor (ER) and/or progesterone receptor (PR) positivity, face challenges in endocrine therapy due to acquired resistance, frequently driven by PI3K/AKT/mTOR pathway activation. This study focuses on the frequency of PIK3CA mutations across molecular subtypes BC within the Indonesian population.
View Article and Find Full Text PDFGreen Seaweed as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research.
Mar Drugs
June 2024
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One of these organisms is , a type of green algae known as green seaweed, seagrapes, or green caviar. This organism stands out because it has great promise for use in medicine, especially in the study of cancer.
View Article and Find Full Text PDFCigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients.
Respir Res
May 2024
School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan.
Article Synopsis
- The study investigates the effects of 20 weeks of cigarette smoke exposure on lung and intestinal microbiomes in mice, utilizing data from COPD patients for comparison.
- Findings reveal that cigarette smoke leads to lung damage, decreased lung capacity, and distinct changes in both lung and intestinal microbiome compositions, indicating dysbiosis.
- The research shows similarities in dysbiosis patterns between mice exposed to cigarette smoke and COPD patients, suggesting a significant link between cigarette smoke exposure and lung disease through microbiome alterations.