7 results match your criteria: "Charité Universitätsmedizin Berlin[Affiliation]"
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia.
Lancet Psychiatry
April 2025
Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Munich, Germany; Deutsches Zentrum für Psychische Gesundheit, München-Augsburg, Germany. Electronic address:
Background: Sedative adverse events are common in patients with schizophrenia undergoing antipsychotic treatment, which affects treatment adherence and the patients' quality of life. Although tolerance to sedation is believed to develop, robust evidence documenting the timing of sedation onset and resolution remains elusive. To address this gap, we aimed to assess the dynamics of onset and resolution of sedation across various antipsychotics in patients with schizophrenia.
View Article and Find Full Text PDFSurgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution.
Life (Basel)
October 2022
Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13351 Berlin, Germany.
Article Synopsis
- Soft tissue sarcomas (STSs) are rare malignant tumors with complex treatment protocols and no definitive guidelines on surgical margin width.
- The study analyzed 169 patients with localized STSs of the extremities or trunk, focusing on the impact of surgical margin width on local and systemic disease-free survival.
- Results indicated that low-grade STSs show better local control with margins of at least 2 mm, while high-grade STSs benefit from intact muscle fascia at the margin, although surgical margin width appears less critical when combined with adjunct radiochemotherapy.
Age-Related Differences in Structure and Function of Nasal Epithelial Cultures From Healthy Children and Elderly People.
Front Immunol
May 2022
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Chariteí - Universitaätsmedizin Berlin, Berlin, Germany.
The nasal epithelium represents the first line of defense against inhaled pathogens, allergens, and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic airways diseases. Despite age-dependent clinical phenotypes triggered by these noxious stimuli, little is known about how aging affects the structure and function of the airway epithelium that is crucial for lung homeostasis and host defense. The aim of this study was therefore to determine age-related differences in structural and functional properties of primary nasal epithelial cultures from healthy children and non-smoking elderly people.
View Article and Find Full Text PDFCharacterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Hypertension
August 2019
From the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Article Synopsis
- - The study investigates how subendocardial damage due to hypertension impacts the structure and function of the heart, highlighting early signs of cardiac problems even in asymptomatic individuals.
- - Mice induced with subendocardial scarring showed diastolic dysfunction, changes in myocardial deformation, and increased expression of specific biomarkers, while systolic function remained normal.
- - Advanced imaging techniques indicated that alterations in myocardial microstructure, particularly in subepicardial myofibers, can serve as early indicators for subendocardial fibrosis, with high sensitivity and specificity for predicting cardiac damage.
Dupilumab in Treatment of Chronic Prurigo: A Case Series and Literature Review.
Acta Derm Venereol
September 2019
Department of Dermatology, Venereology and Allergology, Charité - Universitäätsmedizin Berlin, Berlin, Germany.
Dietary patterns and respiratory health in adults from nine European countries-Evidence from the GA LEN study.
Clin Exp Allergy
November 2018
Population Health and Occupational Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Article Synopsis
- A study analyzed dietary patterns across nine European countries to see how they relate to asthma and allergic symptoms, using a food frequency questionnaire and respiratory symptom assessments from over 3,200 participants aged 15-77.
- Two main dietary patterns were identified: one high in animal proteins and carbohydrates, and the other rich in fruits and vegetables.
- The results indicated that the diet high in animal proteins and carbohydrates was linked to worse asthma outcomes, including higher asthma scores, greater prevalence of current asthma, wheezing, atopic status, and reduced lung function.
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?
Am J Transplant
December 2016
Medical Research Council Centre for Transplantation, King's College London, London, United Kingdom.
We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression of B cell-related genes and the relative expansions of B cell subsets. However, in all of these studies, the index group-namely, the tolerant recipients-were not receiving immunosuppression (IS) treatment, unlike the rest of the comparator groups. We aimed to assess the confounding effect of these regimens and develop a novel IS-independent signature of tolerance.
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