Stepwise approach to alzheimer's disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers.

Early identification of Alzheimer's disease (AD) pathology is essential for timely intervention, particularly in primary care. We evaluated the diagnostic performance of a scalable, multimodal framework in a real-world, population-based cohort. A total of 277 community-dwelling individuals aged ≥ 60 years from the STOP-ALZHEIMER DEBA study (Basque Country, Spain) underwent brief cognitive screening (MMSE, M@T, Fototest, AD8) with optimized cut-offs, along with clinical risk assessment.

Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia.

: Aging is a well-established independent risk factor for both cognitive impairment and sleep disorders, including obstructive sleep apnea (OSA), a modifiable yet underrecognized condition. OSA has been implicated in biological mechanisms contributing to Alzheimer's disease, including amyloid-β accumulation, tau phosphorylation, and neuroinflammation. This underscores the need to optimize OSA diagnosis in individuals with an increased risk of dementia.