Understanding the interplay between epidemiological and social cognitve drivers of behaviour change during the Covid-19 pandemic.

Since the COVID-19 pandemic, there is growing evidence that the social epidemiological context may play a crucial role in the adoption of health protective behaviours in response to emerging infectious diseases. Yet, our understanding of how and why these behaviours are influenced by the epidemiological forces remains relatively limited. This repeated, cross-sectional investigation examines the extent to which the association between the socio-epidemiological context and protective behaviour was mediated by a series of common social cognitive factors from leading models of health behaviour during the COVID-19 epidemic in France.

Cortical map remodeling in the intact hemisphere and functional recovery after focal lesion to the primary somatosensory cortex.

After injury to the primary somatosensory cortex (S1), most studies have focused on perilesional remodeling and its role in functional recovery. In contrast, alterations within the contralesional cortex remain poorly understood, even though the interhemispheric communication is disrupted by the lesion. Using electrophysiological mapping, we investigated in rats the time-course of cutaneous map remodeling in the intact hemisphere following unilateral focal damage to the forepaw area in S1 along with behavioral assessment of sensorimotor deficits.

Reactive and adaptive remodeling of S1 cortical maps correlates with functional deficits and recovery following M1 microinfarct.

Reciprocal connections between the S1 and M1 cortices suggest a crucial role for somatosensory processing in cortical reorganization following M1 injury. However, the specific contribution of S1 to functional recovery after M1 lesions remains unclear. Here, we investigated remodeling of the S1 forepaw map alongside spontaneous sensorimotor recovery following a focal lesion to the caudal forelimb area (CFA) of M1.

A lasting impression.

Touch-sensitive neurons in the fingertips take previous physical contacts into account when relaying tactile information to the brain.

Constraints on sea-level rise during meltwater pulse 1B from the Great Barrier Reef.

The timing, rate, and magnitude of rapid sea-level rise during Meltwater Pulse 1B (MWP-1B, ~11.45-11.1 ka) remain controversial.

Amivantamab in Participants With Advanced NSCLC and MET Exon 14 Skipping Mutations: Final Results From the CHRYSALIS Study.

Introduction: Amivantamab is an EGFR-MET bispecific antibody with immune cell-directing activity. We assessed the safety and efficacy of amivantamab in participants with advanced NSCLC harboring primary MET exon 14 skipping mutations (METex14).

Methods: CHRYSALIS enrolled participants with METex14 NSCLC who progressed after or declined standard-of-care therapy.

How do positive and negative emotions influence children's and adolescents' arithmetic performance?

This study is the first to investigate how negative and positive emotional states influence children's arithmetic performance and age-related differences therein. Children aged 8-14 (n = 149) were asked to verify true/false, one-digit addition problems (i.e.

Antitumor Activity of Vebreltinib and Characterization of Clinicogenomic Features in Solid Tumors with MET Rearrangements.

Unlabelled: Oncogenic translocations involving the MET gene have been reported in several cancer types, but detailed clinicogenomic characterization of these cancers is not well defined. In addition, prospective clinical trials evaluating the antitumor activity of MET inhibitors in MET rearrangement-positive cancers are limited. In this study, in a pan-cancer analysis of >46,000 solid tumors with comprehensive genomic profiling, we identified oncogenic MET rearrangements in ∼0.

Leveraging time for better impulse control: Longer intervals help ADHD children inhibit impulsive responses.

Children diagnosed with an Attention Deficit Hyperactivity Disorder (ADHD) often exhibit impulsivity and timing difficulties. Here, we investigated whether children (mean age =  9.9 years) with combined type ADHD, comprising both hyperactive-impulsive and inattentive symptoms, could use the temporal predictability of an event to help inhibit impulsive behaviour.

Amivantamab Plus Lazertinib in Patients With EGFR-Mutant NSCLC After Progression on Osimertinib and Platinum-Based Chemotherapy: Results From CHRYSALIS-2 Cohort A.

Introduction: Treatment options for patients with EGFR-mutated NSCLC with disease progression on or after osimertinib and platinum-based chemotherapy are limited.

Methods: CHRYSALIS-2 cohort A evaluated amivantamab plus lazertinib in patients with EGFR exon 19 deletion- or L858R-mutated NSCLC with disease progression on or after osimertinib and platinum-based chemotherapy. Primary end point was investigator-assessed objective response rate (ORR).

Hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial.

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) at interval cytoreductive surgery for ovarian cancer improves overall survival but its role in recurrent disease is uncertain. We aimed to compare outcomes in patients treated with or without HIPEC during surgery for recurrent ovarian cancer.

Methods: The multicentre, open-label, randomised, phase 3 CHIPOR trial was conducted at 31 sites in France, Belgium, Spain, and Canada, and enrolled patients with first relapse of epithelial ovarian cancer at least 6 months after completing platinum-based chemotherapy.

Asymmetry and rehabilitation of the subjective visual vertical in unilateral vestibular hypofunction patients.

Aims: Patients with acute unilateral peripheral vestibular hypofunction (AUVP) show postural, ocular motor, and perceptive signs on the diseased side. The subjective visual vertical (SVV) test measures the perceived bias in earth-vertical orientation with a laser line in darkness. This study was aimed at (1) examining whether SVV bias could depend on preset line orientation and angles, and (2) investigating whether vestibular rehabilitation (VR) can improve SVV normalization.

Resolution of Haplotype Ambiguities in Transfusion Settings.

Red blood cell (RBC) transfusion, limited by patient alloimmunization, demands accurate blood group typing. The Rh system requires specific attention due to the limitations of serological phenotyping methods. Although these have been compensated for by molecular biology solutions, some RhCE ambiguities remain unresolved.

Size and shape effects on chemical ordering in Ni-Pt nanoalloys.

The atomic structure and chemical ordering of Ni-Pt nanoalloys of different sizes and shapes are studied by numerical simulations using Monte Carlo methods and a realistic interatomic potential. The bulk Ni-Pt ordering tendency remains in fcc nanoparticles but we show some chemical ordering frustrations linked to surface reconstructions depending on the cluster size and shape. A reversed temperature dependence of Pt surface segregation is also established.

On the distinction between position and order information when processing strings of characters.

To probe the processing of gaze-dependent positional information and gaze-independent order information when matching strings of characters, we compared effects of visual similarity (hypothesized to affect gaze-centered position coding) with the effects of character transpositions (hypothesized to affect the processing of gaze-independent order information). In Experiment 1, we obtained empirical measures of visual similarity for pairs of characters, separately for uppercase consonants and keyboard symbols. These similarity values were then used in Experiment 2 to create pairs of four-character stimuli (four letters or four symbols) that could differ by substituting one character with a different character from the same category that was visually similar (e.

Statistical Associations between Vestibular Pathologies and Hypothyroidism: A Retrospective Study.

The association between vestibular pathologies and thyroid hormone disorders has been known for several decades. However, very little information is available on the types of vestibular symptoms that may be affected by altered thyroid hormone levels. The aim of this study was to provide patient data in order to identify statistical associations between vestibular pathologies and thyroid hormone disorders.

Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset.

Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive.

Arithmetic skills are associated with left fronto-temporal gray matter volume in 536 children and adolescents.

There are large individual differences in arithmetic skills. Although a number of brain-wide association studies have attempted to identify the neural correlates of these individual differences, studies have focused on relatively small sample sizes and have yielded inconsistent results. In the current voxel-based morphometry study, we merged six structural imaging datasets of children and adolescents (from 7.

A Novel Multi-ion Evaluation Scheme to Determine Stable Chlorine Isotope Ratios (Cl/Cl) of Chlordecone by LC-QTOF.

Organochlorinated pesticides are highly persistent organic pollutants having important adverse effects in the environment. To study their fate, compound-specific isotope analysis (CSIA) may be used to investigate their degradation pathways and mechanisms but is currently limited to C isotope ratios. The assessment of Cl isotope ratios from mass spectra is complicated by the large number of isotopologues of polychlorinated compounds.

Influence of the MnGe/Ge ohmic-contact interface on the Seebeck coefficient of the MnGe/Ge bilayer.

Thermoelectricity is a well-known effect that can be used to convert heat energy into electrical energy. However, the yield of this conversion is still low compared to current photovoltaic technology. It is limited by the intrinsic properties of materials, leading to intensive materials science investigations for the design of efficient thermoelectric (TE) materials.

Identification of Follow-Up Markers for Rehabilitation Management in Patients with Vestibular Schwannoma.

This study delves into the absence of prognostic or predictive markers to guide rehabilitation in patients afflicted with vestibular schwannomas. The objective is to analyze the reweighting of subjective and instrumental indicators following surgery, at 7 days and 1 month postoperatively. This retrospective cohort encompasses 32 patients who underwent unilateral vestibular schwannoma surgery at the Marseille University Hospital between 2014 and 2019.

Temporal unpredictability increases error monitoring as revealed by EEG-EMG investigation.

Reacting in an unpredictable context increases error monitoring as evidenced by greater error-related negativity (ERN), an electrophysiological marker linked to an evaluation of response outcomes. We investigated whether ERN also increased when participants evaluated their responses to events that appeared in unpredictable versus predictable moments in time. We complemented electroencephalographic (EEG) analysis of cortical activity by measuring performance monitoring processes at the peripheral level using electromyography (EMG).