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The responses to different ovarian stimulation schedules were studied in women which underwent in programs of assisted fertilization. The follicular development and seric estradiol with the number and quality of the retrieved oocytes. Were correlated 49 patients and divided in 3 groups according to ovarian stimulation schedule were analyzed. The stimulation was followed day by day with seric estradiol and ultrasound follicular measurement. With the three schedules were retrieved 205 oocytes, being mature 179, immature 9 and 17 atretic, there was no significant difference between the different schedules.
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Front Endocrinol (Lausanne)
September 2025
Gynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Introduction: Several studies indicate that a specific genotype profile could influence ovarian sensitivity to exogenous gonadotropin. However, most of the previous studies were observational and retrospective and thereby more prone to bias. The aim of this study was to evaluate the impact of gonadotropin single nucleotide polymorphisms (SNPs) on the outcomes of fertilization (IVF) in infertile patients undergoing their first ovarian stimulation (OS) cycle.
View Article and Find Full Text PDFJ Assist Reprod Genet
September 2025
Morsani College of Medicine, Department of Obstetrics and Gynecology, University of South Florida, 2 Tampa General Circle, STC 6th Floor, Tampa, FL, 33606, USA.
Purpose: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A similar association has been found in intrauterine insemination (IUI) cycles using gonadotropins for ovulation induction.
View Article and Find Full Text PDFHum Reprod
September 2025
Department of Philosophy and Moral Sciences, Bioethics Institute Ghent, Ghent University, Ghent, Belgium.
Study Question: What information does an international group of professionals and egg donors consider relevant and morally necessary for prospective egg donors to provide valid informed consent?
Summary Answer: Participants considered 80% of all concrete information items (CIIs) to be relevant (e.g. all legal aspects) and 67% to be morally necessary.
Study Question: Can patient age and ovarian reserve tests predict the number of cryopreserved oocytes in patients undergoing one or more ovarian stimulation cycles for elective oocyte cryopreservation (EOC)?
Summary Answer: A predictive model incorporating patient age, antral follicle count (AFC), anti-Müllerian hormone (AMH), and FSH levels achieved the greatest predictive accuracy.
What Is Known Already: As a consequence of societal evolution, women are increasingly delaying starting a family. However, the natural decline in ovarian reserve and oocyte quality as age advances can increase the risk of age-related fertility decline (ARFD) and involuntary childlessness.
Hum Reprod
September 2025
Boston IVF-IVIRMA Global Research Alliance, Waltham, MA, USA.
Study Question: Does a high proportion of immature oocytes impact embryo development and live birth rates in IVF-ICSI cycles?
Summary Answer: While a high proportion of immature oocytes is associated with lower blastocyst formation and reduced preimplantation genetic testing for aneuploidy (PGT-A) utilization, live birth rates remain comparable when key confounders-such as age, BMI, gonadotropin dosage, and metaphase-II (MII) count-are balanced, but cycles with a very low MII proportion resulted in fewer embryo transfers, which is quantitatively limiting, even if embryo quality appears unaffected.
What Is Known Already: Previous studies have linked a lower proportion of mature oocytes (MII) to decreased fertilization rates, abnormal embryo development, and lower pregnancy and live birth rates. However, it remains unclear whether these outcomes are due to quantitative limitations (fewer mature oocytes available) or qualitative deficiencies (intrinsic oocyte quality issues).