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Regarding: 'impact of parathyroid gland classification on hypoparathyroidism following total thyroidectomy with central neck dissection for differentiated thyroid cancer'.
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Evaluating Vitamin D Deficiency-Linked Digestive Issues by Bridging Endocrinology With Gastrointestinal Disorders.
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Biochemistry, Liaquat University of Medical and Health Sciences, Karachi, PAK.
Background: Vitamin D insufficiency is increasingly recognized as a significant and underlying contributor to a wide range of musculoskeletal disorders, particularly in gastrointestinal (GI) and endocrine health. The study aims to determine the clinical relationship between vitamin D status and the severity of GI symptoms, while also assessing the impact of related endocrine disturbances.
Methods: A cross-sectional study was conducted involving 120 adult patients with GI problems, including constipation, bloating, irritable bowel syndrome (IBS), and dyspepsia in a tertiary care hospital over a six-month duration.
The Application of Assay- and Age-Specific Parathyroid Hormone (PTH) Reference Intervals Decreases the Diagnosis of Normocalcaemic Primary Hyperparathyroidism and Improves Diagnostic Concordance of PTH Assays.
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Parathyroid hormone (PTH) assays are not standardized and therefore PTH results are interpreted using manufacturer-provided assay-specific reference intervals. Assay-specific PTH reference intervals, however, do not account for between-assay differences and lead to discordance in the diagnosis of normocalcaemic primary hyperparathyroidism (NCPHPT). PTH increases with age independent of vitamin D, renal function, phosphate and ionized calcium.
View Article and Find Full Text PDFBone health in cancer: perspective on the use of osteoanabolic agents.
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Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 E 74th Street, New York, NY 10021, USA.
Cancer negatively impacts bone health through various mechanisms, including treatment-induced bone loss and malignant bone lesions, often leading to increased fracture risk and higher morbidity and mortality. Antiresorptive agents (bisphosphonates and denosumab) are the current standard of care to reduce the risk of skeletal-related events and prevent treatment-related fragility fractures in patients with cancer. While there is strong evidence to support their benefits in cancer, there is potential room for further reduction in the risk of pathologic and fragility fractures.
View Article and Find Full Text PDFTransoral Endoscopic and Minimally Invasive Thyroidectomy.
JAMA Surg
September 2025
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Importance: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a scarless surgical technique gaining popularity; however, its safety, cost, and impact on pathological evaluation compared with minimally invasive nonendoscopic thyroidectomy (MINET) remain under evaluation.
Objective: To compare surgical outcomes, pathological considerations, and cost profiles following TOETVA vs MINET using a propensity-matched cohort.
Design, Setting, And Participants: This cohort study included 720 patients undergoing oncoplastic thyroidectomy between January 2021 and January 2023, with 12-month follow-up, at a tertiary referral center in Taipei, Taiwan.