A Study on Correlation between Red Cell Distribution Width to Platelet Ratio (RPR) and Child Turcotte Pugh Score in Patients of Chronic Liver Disease at Tertiary Care Center of Jharkhand.

Background: It was hypothesized that high red cell distribution width (RDW) due to anemia and the low platelet count due to cirrhosis studies impacts the RDW to platelet ratio (RPR), which can be used as a predictor of significant fibrosis and cirrhosis. For evaluation of the severity of liver disease Child-Turcotte-Pugh (CTP) score is universally used.

Aims: To determine the correlation between RPR with CTP severity score in patients of chronic liver disease (CLD), and to evaluate the severity of CLD indirectly with RPR.

Methods: This is a cross-sectional study of 100 patients diagnosed with CLD, conducted in RIMS Ranchi between February 2021 and July 2022. The categorical data were evaluated by the test of proportion, Chi-square, Fisher's exact test as appropriate. The correlation between RPR and CTP total score and class was analyzed using Pearson correlation in SPSS version 22.

Results: The mean RDW-coefficient of variation (measurement of red blood cell volume width deviation), referred to as volume curve width for the study population, was 17.1 ± 3.2, while the median and mode were 16.4. The range is between 12.4 and 30.7. The mean platelet value for the study population was 93,522/μl ± 38,756, while the median was 86,000. Univariate Regression Analysis: RPR with a P = 0.001, β = 7.869, t = 4.729, and r2 = 0.186 depicts that the model explains 18.6% of the variance in the total CTP score.

Conclusion: RPR holds the potential for evolving as a novel noninvasive marker for assessing the severity of CLD.