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An experiment using a predictive learning task with college students evaluated the impact of a stimulus associated with extinction on an AAB renewal design. Four groups of participants learned a specific relationship between two cues (X and Y) and two outcomes (O1 and O2) in Context A during the first phase. Subsequently, both cues were subjected to extinction in the same Context A. During the Test, extinction was in effect for both cues; one group experienced it in Context A (AAA), while the other three groups were tested in a second Context B. We observed a reduction in the AAB renewal effect when participants received a stimulus associated with extinction (AAB*), but not when testing involved presenting a new stimulus (AAB). However, the reductive effect of the extinction reminder was not observed when the stimulus was presented only during the 75% of the extinction trials (AAB*75). These findings suggest that, under certain circumstances, the level of association of the extinction reminder with extinction might affect its efficacy in reducing response recovery.
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http://dx.doi.org/10.3758/s13420-025-00683-2 | DOI Listing |
Learn Behav
September 2025
Universidad Nacional Autónoma de México, Mexico, Mexico.
An experiment using a predictive learning task with college students evaluated the impact of a stimulus associated with extinction on an AAB renewal design. Four groups of participants learned a specific relationship between two cues (X and Y) and two outcomes (O1 and O2) in Context A during the first phase. Subsequently, both cues were subjected to extinction in the same Context A.
View Article and Find Full Text PDFFront Neurosci
April 2025
Daniel K. Inouye Graduate School of Nursing, Uniformed Services University, Bethesda, MD, United States.
Introduction: Ketamine, a multimodal dissociative anesthetic, is widely used as a trauma analgesic in emergency situations. Ketamine is also used to treat psychiatric disorders due to its broad application potential, including treatment-resistant major depression. However, its impacts on the development of post-traumatic stress disorder (PTSD) and its potential as a treatment for PTSD are controversial.
View Article and Find Full Text PDFBackground: Drug-related memories can hinder abstinence goals in drug addiction. Promoting non-drug memories via ventromedial prefrontal cortex- (vmPFC) and amygdala-guided extinction yields mixed success. Post-retrieval extinction (RE) destabilizes and updates memories during reconsolidation, improving extinction.
View Article and Find Full Text PDFWellcome Open Res
May 2025
South African Medical Council Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, 7550, South Africa.
Background: Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies.
View Article and Find Full Text PDFEur J Psychotraumatol
December 2025
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Posttraumatic stress disorder (PTSD) and chronic pain are devastating conditions that often co-occur. Current understanding of comorbid PTSD and chronic pain is limited, and treatment options are undereffective. This paper presents a theoretical basis for conceptualising chronic pain symptoms within Emotional Processing Theory (EPT), the foundation for Prolonged Exposure (PE), an effective treatment for PTSD.
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