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http://dx.doi.org/10.3760/cma.j.cn112151-20250512-00338 | DOI Listing |
Pediatr Ann
September 2025
Pediatric Gynecology Program, Children's National Hospital, Washington, DC.
Abnormal uterine bleeding (AUB), a common gynecologic concern in adolescents, often leads to significant physical and emotional distress. This article provides a comprehensive overview of AUB in adolescence, including classification, common causes, diagnosis, and management. The physiology of the hypothalamic-pituitary-ovarian axis is reviewed, highlighting its role in menstrual regulation and the immaturity-related anovulation that commonly contributes to AUB in the first 2 to 3 years after menarche.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Hum Reprod
September 2025
Boston IVF-IVIRMA Global Research Alliance, Waltham, MA, USA.
Study Question: Does a high proportion of immature oocytes impact embryo development and live birth rates in IVF-ICSI cycles?
Summary Answer: While a high proportion of immature oocytes is associated with lower blastocyst formation and reduced preimplantation genetic testing for aneuploidy (PGT-A) utilization, live birth rates remain comparable when key confounders-such as age, BMI, gonadotropin dosage, and metaphase-II (MII) count-are balanced, but cycles with a very low MII proportion resulted in fewer embryo transfers, which is quantitatively limiting, even if embryo quality appears unaffected.
What Is Known Already: Previous studies have linked a lower proportion of mature oocytes (MII) to decreased fertilization rates, abnormal embryo development, and lower pregnancy and live birth rates. However, it remains unclear whether these outcomes are due to quantitative limitations (fewer mature oocytes available) or qualitative deficiencies (intrinsic oocyte quality issues).
Radiol Case Rep
November 2025
Department of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Malignant ovarian germ cell tumors are rare in the pediatric population, particularly in children under ten years of age. We report a unique case of a mixed germ cell tumor, comprising dysgerminoma, mature and immature teratomas, and yolk sac tumor, located on an ectopic ovary, which was discovered following adnexal torsion in a 9-year-old girl with a family history of gynecological cancers. Mixed germ cell tumors present significant diagnostic challenges due to their heterogeneous histological composition and complex biological behavior.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, 566 Nonhyeon-ro, Gangnam-gu, Seoul 06135, Republic of Korea.
The aim of this study was to determine the age-specific characteristics of ovarian teratoma and associated malignancies. This retrospective single-centre cohort study included 2181 women with ovarian teratoma who underwent surgery at our institution between January 2008 and April 2019. Malignancies associated with ovarian teratoma were divided into immature teratoma, combined ovarian malignancy, and malignant transformation of mature cystic teratoma.
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