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Conservation policies often need to integrate scientific predictions with ethical considerations. However, different normative ethical systems at the root of conservation approaches often support different decisions, and the moral stances of stakeholders are influenced by diverse societal values and perceptions. This creates the potential for dilemmas and conflicts. In the present article, we adapt the well-known trolley problem thought experiment to a conservation context. Exploring variations in how the problem is framed enables us to highlight key concepts that need to be considered in decision-making (uncertainty; asymmetry in numbers, victims, and impacts; temporal and spatial asymmetry; causal relationships and stakeholder involvement). We argue that the trolley problem offers a simplified but flexible framework to understand and predict the factors underlying differences in moral stances across diverse conservation issues, foster communication, and facilitate informed decision-making in conservation practice.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412296 | PMC |
http://dx.doi.org/10.1093/biosci/biaf052 | DOI Listing |
Bioscience
September 2025
South African National Biodiversity Institute, Kirstenbosch Research Centre, Cape Town.
Conservation policies often need to integrate scientific predictions with ethical considerations. However, different normative ethical systems at the root of conservation approaches often support different decisions, and the moral stances of stakeholders are influenced by diverse societal values and perceptions. This creates the potential for dilemmas and conflicts.
View Article and Find Full Text PDFRinsho Ketsueki
September 2025
Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University.
AIDS-related malignant lymphomas (ARL) are lymphomas that develop in association with HIV infection. Although the introduction of combination antiretroviral therapy (cART) has markedly improved the life expectancy of people living with HIV (PLWH), approximately one-third of PLWH, including some with well controlled disease, still die from HIV-associated malignancies. HIV itself is not tumorigenic, and most of these tumors are due to co-infection with oncogenic viruses.
View Article and Find Full Text PDFInt J Cancer
August 2025
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in hematologic malignancies, but antigen escape remains a major challenge, especially in solid tumors, where the tumor microenvironment (TME) exacerbates the problem. Mechanisms of antigen escape include antigen loss, epitope masking, lineage switching, and trogocytosis-mediated CAR dysfunction. The TME promotes immune evasion through physical barriers, immunosuppressive cells, and metabolic competition.
View Article and Find Full Text PDFTher Adv Med Oncol
August 2025
Department of Hematology, The First Affiliated Hospital of Soochow University, and Jiangsu Institute of Hematology, Suzhou 215000, China.
The heterogeneity of lymphoma responses to various treatments remains a significant challenge in clinical practice. Emerging evidence implicates the potential role of the gut microbiome in lymphoma pathogenesis and progression. Advances in high-throughput sequencing and metabolomics have significantly enhanced our understanding of the complex interaction between the gut microbiome and lymphoma.
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