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http://dx.doi.org/10.1002/hon.70133 | DOI Listing |
Ther Adv Drug Saf
August 2025
Clinical Pharmacy Service, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Via E.Tricomi n. 5, Palermo 90127, Italy.
Background: Cholangiocarcinoma (CCA) is a cancer with a low survival rate. New drugs targeting molecular alterations, oncogenic mutations, and gene fusions are being tested as second-line treatments.
Objectives: This systematic review aims to summarize the results obtained with three new targeted therapies-pemigatinib, futibatinib, and ivosidenib-for the treatment of CCA, evaluating their safety and tolerability profiles in patients, compared to current standard therapies.
Quant Imaging Med Surg
May 2025
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Iron is associated with the pathophysiology of gliomas. The measurement of brain iron levels plays a vital role in defining the pathophysiologic changes caused by gliomas. This study aimed to analyze the effect of gliomas with different histopathology and molecular characteristics on deep gray matter (DGM) iron content and the relationship between DGM iron content and cognition in glioma patients (PT).
View Article and Find Full Text PDFInt J Mol Sci
April 2025
Bioinformatics Group, Institute of Molecular Biology National Academy of Sciences of the Republic of Armenia (NAS RA), Yerevan 0014, Armenia.
Telomere maintenance mechanisms (TMMs) play a critical role in cancer biology, particularly in lower-grade gliomas (LGGs), where telomere dynamics and pathway activity remain poorly understood. In this study, we analyzed TCGA-LGG and CGGA datasets, focusing on telomere length variations, pathway activity, and survival data across IDH subtypes. Additional validation was performed using the GEO COPD and GBM datasets, ensuring consistency in data processing and batch effect correction.
View Article and Find Full Text PDFClin Neurol Neurosurg
June 2025
Cingulum Health, Sydney, Australia. Electronic address:
Introduction: Gliomas pose a significant treatment challenge due to their varied genetic makeup and clinical presentations. This study examines a unique cohort of high-grade adult type diffuse gliomas (ATDG) previously diagnosed as anaplastic astrocytoma prior to the WHO 2021 tumor classification changes. This cohort chose to undergo only surgical resection without adjuvant therapies.
View Article and Find Full Text PDF