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Purpose: Measuring pain in various settings, such as hospitals or long-term care facilities, is commonly done through the use of numerical pain assessment scales, e.g. the Numeric Rating Scale. While cut-off points are already used in daily practice for pain management and quality monitoring, a better understanding of these thresholds is needed.The aim of this study is to identify cut-off points for different pain intensities on the Numeric Rating Scale in the existing Literature.
Design: Literature study.
Methods: The literature search aimed to identify articles that establish independent cut-off points for pain levels on the Numeric Rating Scale. PubMed and Embase were searched using an identical search string. Additionally, the grey literature was reviewed on Google Scholar. Papers were screened for relevancy using Rayyan. The data was extracted using a data abstraction manual and synthesised to describe the findings.
Results: A total of 21 papers were included in the overview of pain cut-off points. The identified cut-off points for pain vary widely across studies, with definitions of pain encompassing between one and five levels. Values for mild pain ranged between scores 0 and 5, with the most cited range being 1-4. Moderate pain ranged from 3 to 8, with 4-8 as the most cited range. Severe pain ranged from 5 to 10, with the most popular category of 7-10. There was little consistency between studies even within similar populations, highlighting the lack of consensus. A debate persists regarding the use of a single cut-off point versus a range, with some studies advocating for overlapping ranges while others support nonoverlapping thresholds.
Conclusion: Establishing a cut-off value for pain is challenging, with no consensus in the literature on what constitutes optimal values. This variability may be attributed to differences in study populations, pain type and study methodologies. This emphasizes the need for alternative assessment tools or the inclusion of additional measures alongside the NRS. It is crucial to reassess the current pain assessment guidelines that continue to rely on these cut-off points in clinical practice, as well as to reconsider policies that use cut-offs for quality monitoring.
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http://dx.doi.org/10.1016/j.pmn.2025.08.005 | DOI Listing |
RMD Open
September 2025
Department of Rheumatology and Department of Internal Medicine, Ghent University Hospital, Unit for Molecular Immunology and Inflammation, Flemish Institute for Biotechnology, Inflammation Research Center, University of Ghent, Ghent, Belgium.
Objectives: To evaluate whether patients with systemic lupus erythematosus (SLE) have different nailfold videocapillaroscopy (NVC) findings compared with healthy controls (HCs) and whether there is an association between NVC abnormalities and disease activity, clinical and/or laboratory features in SLE.
Methods: This is an observational, multicentre, international, matched case-control study. 381 subjects (203 patients with SLE and 178 HCs) were enrolled from 16 centres in 10 countries.
Arch Phys Med Rehabil
September 2025
REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium; UMSC, Hasselt-Pelt, Belgium. Electronic address:
Objective: To investigate the prevalence and magnitude of dual-task (DT) difficulties and the discriminative ability of three questionnaires evaluating perceived DT difficulties: the Dual-Tasking Questionnaire (DTQ), Dual-Task Screening-List (DTSL), and Dual-Task-Impact on Daily-life Activities Questionnaire (DIDA-Q).
Design: Multicenter, cross-sectional study SETTING: Persons with multiple sclerosis (pwMS) and healthy controls (HC) were recruited from 7 multiple sclerosis centers across 6 countries (Belgium, Chile, Italy, Israel, Spain, and Turkey).
Participants: A total of 540 participants: 175 with mild disability (mean EDSS: 2.
Background: At present, existing risk scores together with traditional biomarkers such as troponin and brain natriuretic peptide (BNP) are still unable to accurately predict cancer therapy-related cardiac dysfunction (CTRCD). MicroRNAs (miRNAs) have emerged as promising biomarkers for improved identification of high-risk patients; however, limited studies have been performed in patients with HER2-positive breast cancer.
Objectives: To investigate the predictive potential of six serum-derived circulating miRNAs for CTRCD occurrence in patients with early-stage HER2-positive breast cancer receiving trastuzumab (TTZ).
Introduction: The residual risk of chronic kidney disease (CKD) progression remains high in clinical trials of kidney protective drugs in patients with diabetic kidney disease (DKD).
Methods: In a prospective study, we assessed whether 16 plasma and 10 urine cytokine levels can inform the residual risk of CKD progression in 93 incident patients with DKD treated by Nephrology according to clinical guidelines.
Results: Plasma and urine levels of 12 plasma and 7 urinary cytokines differed between patients with DKD and from healthy controls.
J Intensive Care Med
September 2025
Medical Intensive Care Unit, 108 Military Central Hospital, Hanoi, Vietnam.
Background: Bedside ultrasound is increasingly utilized to assess muscle mass in critically ill patients, providing a noninvasive and real-time tool for early risk stratification. Muscle wasting is known to be associated with adverse outcomes in septic shock, but its prognostic value using ultrasound in this population remains underexplored. This study aimed to investigate the association between changes in rectus femoris cross-sectional area (CSA), assessed by bedside ultrasound, and 28-day mortality in patients with septic shock.
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