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http://dx.doi.org/10.1016/j.otsr.2025.104412 | DOI Listing |
Acta Anaesthesiol Scand
October 2025
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Introduction: Sepsis remains a leading cause of mortality, with mortality from septic shock exceeding 40%. Standardized resuscitation (30 mL/kg) may cause adverse outcomes, including fluid overload or prolonged hypotension, emphasizing the need for individualized strategies. Sepsis-induced shock arises from varying degrees of vasodilation and hypovolemia, yet patients often present with similar clinical signs in the emergency department (ED).
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October 2025
Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Background: Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro- and anti-inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Methods: In this secondary, explorative analysis of a prospective single-centre cohort (n = 459), we assessed associations between endotheliopathy biomarkers (syndecan-1, soluble thrombomodulin (sTM), platelet endothelial cell adhesion molecule-1 (PECAM-1)) and inflammatory biomarkers (pro-inflammatory: IFN-ϒ, IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF-α; anti-inflammatory: IL-4, IL-10, IL-13) at ICU admission using linear regression.
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
J Back Musculoskelet Rehabil
September 2025
Neurology, Akdeniz University, Antalya, Turkey.
BackgroundSpinal cord injury is a complex condition affecting millions globally, often requiring extensive rehabilitation. YouTube is increasingly utilized by spinal cord injury-patients and caregivers for rehabilitation information, despite potential misinformation risks. However, few studies have assessed the quality of spinal cord injury -related content on this platform.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Introduction: TikTok has emerged as a popular platform for sharing medical insights, but concerns exist regarding disseminating inaccurate information on medical conditions, potentially harming patient care. This study aims to evaluate the quality and reliability of TikTok videos on uterine fibroid embolization (UFE). It also examines how video engagement and content quality vary based on the uploader type and video style.
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