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Aggressive driving is a major contributor to traffic fatalities, necessitating reliable assessment methods to guide driver interventions. Existing methods, however, lack granularity in assessing both the severity and specific maneuver categories of aggressive driving behaviors. This paper proposes a novel framework for multidimensional aggressiveness assessment using lateral-longitudinal acceleration and vehicle speed. The framework combines domain-specific prior knowledge with a non-parametric statistical method to quantify aggressiveness levels and automatically extract aggressive driving samples. We then classify them into distinct maneuver categories through fuzzy clustering and semantic analysis, assigning each sample a membership degree for every category. Finally, we integrate the samples' levels with their membership distribution across the maneuvers to generate comprehensive profiles of individuals' driving aggressiveness. Experimental validation with real-world driving data (N=90 drivers) and real-time in-vehicle testing confirms our framework's effectiveness and practicality. Additionally, a spatiotemporal analysis of driving maneuvers reveals insights into the evolution of aggressive driving and its relationship with environmental factors.
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http://dx.doi.org/10.1016/j.aap.2025.108225 | DOI Listing |
Clin Cancer Res
September 2025
University of Michigan-Ann Arbor, Ann Arbor, MI, United States.
Purpose: Liposarcoma (LPS) is the most common soft tissue sarcoma. Well-differentiated LPS (WDLPS) can progress to dedifferentiated LPS (DDLPS), a more aggressive form with higher metastatic potential and poor response to existing therapies. Progress in understanding and treating LPS has been limited.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34051, Republic of Korea.
Microscopic examination of biopsy tissues remains essential for cancer diagnosis, despite advancements in sequencing technologies. Alterations in nuclear size or the nuclear-to-cytoplasmic ratio are hallmark features of cancer cells and often correlate with disease progression. However, the mechanisms underlying nuclear size abnormalities and their impact on tumor progression remain unclear.
View Article and Find Full Text PDFDev Cell
September 2025
Division of Surgical Sciences, Department of Surgery, UC San Diego Health, 3855 Health Sciences Drive, La Jolla, CA 92037, USA. Electronic address:
In this issue of Developmental Cell, Li et al. show that ETS variant transcription factor 1 (Etv1) SUMOylation not only maintains cancer stem cells (CSCs) but also enables their communications with non-CSC cancer cells to induce tumorigenesis of non-CSCs. The finding reveals a new function of CSCs in driving aggressive tumorigenesis that is SUMOylation dependent.
View Article and Find Full Text PDFTher Adv Hematol
September 2025
Department of Hematology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, Shandong 266000, China.
Myelodysplastic syndromes (MDS), particularly in older adults aged 60 years and above, present significant therapeutic challenges due to poor prognosis and limited treatment options. Higher-risk MDS (HR-MDS), defined by the Revised International Prognostic Scoring System score of ⩾3.5, is characterized by increased myeloblasts, severe cytopenia, and a median survival of <2 years.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Faculty of Applied Sciences, Macao Polytechnic University, Macao. Electronic address:
Osteosarcoma (OS), the most prevalent primary bone malignancy in adolescents, is characterized by aggressive progression and early metastasis. However, the epigenetic drivers of its metastatic heterogeneity remain poorly understood. Herein, we integrated bulk DNA methylation profiling and single-cell RNA sequencing (scRNA-seq) to elucidate the epigenetic mechanisms driving OS metastatic heterogeneity.
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