98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.ijrobp.2025.03.084 | DOI Listing |
CHEST Pulm
June 2025
Department of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City KS.
Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) portends a devastating prognosis for patients, with survival typically being < 5 to 8 years after diagnosis. Limited clinical trial data exist to guide treatment strategies, and the efficacy of current strategies-immunomodulation and antifibrotics-remains uncertain. Large randomized controlled trials are costly, but pragmatic trial designs could reduce expenses.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
October 2025
Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
BMJ Open Respir Res
September 2025
Newcastle University, Newcastle Upon Tyne, UK.
Bronchiectasis is a heterogeneous lung disease. There is an increasing focus on personalised medicine in bronchiectasis, with targeted pharmacological interventions for inflammation, immunology and infection. Airway clearance techniques (ACTs) are non-pharmacological treatments used to manage bronchiectasis.
View Article and Find Full Text PDFBMJ
September 2025
Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia
Importance: When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of these studies is not available.
Objective: To develop consensus based guidance for reporting observational studies performed to estimate causal effects by explicitly emulating a target trial.
Gynecol Oncol
September 2025
Division of Gynecologic Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA; Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery, Mayo Clinic, Rochester, MN, USA. Electronic address: